Expression of KCNMA1 in cancer - Summary

GENERAL INFORMATION
Gene name	KCNMA1
Gene description	Potassium channel, calcium activated large conductance subfamily M alpha, member 1
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (PC-3, U-138 MG, U-87 MG)
HPA (normal tissue):	Tissue enhanced (smooth muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA054648
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA054648

GENE INFORMATION
Gene name	KCNMA1 (HGNC Symbol)
Synonyms	KCa1.1, mSLO1, SLO
Description	Potassium channel, calcium activated large conductance subfamily M alpha, member 1 (HGNC Symbol)
Entrez gene summary	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	76869601 - 77638595
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156113 (version 83.38)
Entrez gene	3778
UniProt	Q12791 (UniProt - Evidence at protein level)
neXtProt	NX_Q12791
Antibodypedia	KCNMA1 antibodies

PROTEIN BROWSER

KCNMA1-001	KCNMA1-002	KCNMA1-003	KCNMA1-004	KCNMA1-005	KCNMA1-006	KCNMA1-007	KCNMA1-008	KCNMA1-009	KCNMA1-010	KCNMA1-011	KCNMA1-014	KCNMA1-015	KCNMA1-018	KCNMA1-019	KCNMA1-020	KCNMA1-021	KCNMA1-201	KCNMA1-202	KCNMA1-203	KCNMA1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNMA1-001 ENSP00000286627 ENST00000286627	Q12791 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006970 [response to osmotic stress] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0034465 [response to carbon monoxide] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0043065 [positive regulation of apoptotic process] GO:0045794 [negative regulation of cell volume] GO:0046872 [metal ion binding] GO:0051592 [response to calcium ion] GO:0055085 [transmembrane transport] GO:0060072 [large conductance calcium-activated potassium channel activity] GO:0060073 [micturition] GO:0060083 [smooth muscle contraction involved in micturition] GO:0070062 [extracellular exosome] GO:0071805 [potassium ion transmembrane transport] Show all	1178 aa 131 kDa	No	7
KCNMA1-002 ENSP00000361498 ENST00000372421	H0Y382 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1152 aa 128.9 kDa	No	7
KCNMA1-003 ENSP00000361517 ENST00000372440	A0A0A0MRR0 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1177 aa 130.9 kDa	No	7
KCNMA1-004 ENSP00000361480 ENST00000372403	H0Y379 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1182 aa 132.7 kDa	No	7
KCNMA1-005 ENSP00000361485 ENST00000372408	Q5SVK0 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1167 aa 131.4 kDa	No	7
KCNMA1-006 ENSP00000361514 ENST00000372437	Q5SVK5 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1171 aa 131.8 kDa	No	7
KCNMA1-007 ENSP00000396608 ENST00000457953	Q5SVJ9 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1209 aa 135.4 kDa	No	7
KCNMA1-008 ENSP00000385717 ENST00000404771	Q5SVJ8 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1288 aa 143.5 kDa	No	7
KCNMA1-009 ENSP00000286628 ENST00000286628	Q12791 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006970 [response to osmotic stress] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0007605 [sensory perception of sound] GO:0007623 [circadian rhythm] GO:0007628 [adult walking behavior] GO:0008076 [voltage-gated potassium channel complex] GO:0009897 [external side of plasma membrane] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019228 [neuronal action potential] GO:0030007 [cellular potassium ion homeostasis] GO:0032344 [regulation of aldosterone metabolic process] GO:0034465 [response to carbon monoxide] GO:0034765 [regulation of ion transmembrane transport] GO:0042311 [vasodilation] GO:0042391 [regulation of membrane potential] GO:0042491 [auditory receptor cell differentiation] GO:0043065 [positive regulation of apoptotic process] GO:0043195 [terminal bouton] GO:0045211 [postsynaptic membrane] GO:0045475 [locomotor rhythm] GO:0045794 [negative regulation of cell volume] GO:0046541 [saliva secretion] GO:0046872 [metal ion binding] GO:0048469 [cell maturation] GO:0050885 [neuromuscular process controlling balance] GO:0051260 [protein homooligomerization] GO:0051592 [response to calcium ion] GO:0055085 [transmembrane transport] GO:0060072 [large conductance calcium-activated potassium channel activity] GO:0060073 [micturition] GO:0060082 [eye blink reflex] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060087 [relaxation of vascular smooth muscle] GO:0070062 [extracellular exosome] GO:0071805 [potassium ion transmembrane transport] Show all	1236 aa 137.6 kDa	No	7
KCNMA1-010 ENSP00000361520 ENST00000372443	Q5SVJ7 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1205 aa 133.9 kDa	No	7
KCNMA1-011 ENSP00000402150 ENST00000434208	H0Y5Z6 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071805 [potassium ion transmembrane transport] Show all	886 aa 99.4 kDa	No	2
KCNMA1-014 ENSP00000475086 ENST00000481070	S4R453 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	128 aa 13 kDa	No	1
KCNMA1-015 ENSP00000474686 ENST00000480683	Q12791 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003779 [actin binding] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006813 [potassium ion transport] GO:0006970 [response to osmotic stress] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0034465 [response to carbon monoxide] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0043065 [positive regulation of apoptotic process] GO:0045794 [negative regulation of cell volume] GO:0046872 [metal ion binding] GO:0051592 [response to calcium ion] GO:0060072 [large conductance calcium-activated potassium channel activity] GO:0060073 [micturition] GO:0060083 [smooth muscle contraction involved in micturition] GO:0070062 [extracellular exosome] GO:0071805 [potassium ion transmembrane transport] Show all	168 aa 17.2 kDa	No	1
KCNMA1-018 ENSP00000388370 ENST00000450795	H0Y406 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	264 aa 29.8 kDa	No	0
KCNMA1-019 ENSP00000402254 ENST00000428546	H0Y606 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0071805 [potassium ion transmembrane transport] Show all	180 aa 20.5 kDa	No	0
KCNMA1-020 ENSP00000473714 ENST00000604624	S4R2X4 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1042 aa 117.3 kDa	No	6
KCNMA1-021 ENSP00000485867 ENST00000626620	Q12791 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003779 [actin binding] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006970 [response to osmotic stress] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030007 [cellular potassium ion homeostasis] GO:0034465 [response to carbon monoxide] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0043065 [positive regulation of apoptotic process] GO:0045794 [negative regulation of cell volume] GO:0046872 [metal ion binding] GO:0051592 [response to calcium ion] GO:0055085 [transmembrane transport] GO:0060072 [large conductance calcium-activated potassium channel activity] GO:0060073 [micturition] GO:0060083 [smooth muscle contraction involved in micturition] GO:0070062 [extracellular exosome] GO:0071805 [potassium ion transmembrane transport] Show all	1219 aa 135.5 kDa	No	7
KCNMA1-201 ENSP00000346321 ENST00000354353	A0A0A0MRC3 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1071 aa 121.1 kDa	No	6
KCNMA1-202 ENSP00000385806 ENST00000404857	A0A0A0MSE6 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1014 aa 114.3 kDa	No	6
KCNMA1-203 ENSP00000385552 ENST00000406533	J3KQ16 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	1040 aa 117.1 kDa	No	6
KCNMA1-204 ENSP00000482747 ENST00000618048	A0A087WZL8 [Direct mapping] Calcium-activated potassium channel subunit alpha-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	213 aa 22.2 kDa	No	1