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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADAMTS3
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAMTS3

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 3

Protein class

Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, HEL, K-562, U-2 OS)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA021368 , HPA021369
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021368
HPA021369

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A majority of cancer tissues displayed moderate cytoplasmic and nuclear positivity. A few cases of melanomas, colorectal and ovarian cancers displayed strong positivity. A few cases of lymphoma were weakly stained or negative.

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A majority of cancer tissues showed weak to moderate cytoplasmic and nuclear positivity. Several cases of breast cancers displayed strong cytoplasmic positivity. Several cases of lymphomas were negative.

GENE INFORMATION

Gene name

ADAMTS3 (HGNC Symbol)

Synonyms

ADAMTS-4, KIAA0366

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q13.3

Chromosome location (bp)

72280969 - 72568799

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156140 (version 83.38)

Entrez gene

9508

UniProt

O15072 (UniProt - Evidence at transcript level)

neXtProt

NX_O15072

Antibodypedia

ADAMTS3 antibodies

PROTEIN BROWSER

ADAMTS3-001
ADAMTS3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS3-001
ENSP00000286657
ENST00000286657
O15072 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 3
Show all
Enzymes
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0010573 [vascular endothelial growth factor production]
GO:0016485 [protein processing]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032964 [collagen biosynthetic process]
GO:0043206 [extracellular fibril organization]
GO:0070062 [extracellular exosome]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
Show all
1205 aa
135.6 kDa
Yes 0
ADAMTS3-201
ENSP00000480055
ENST00000622135
O15072 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 3
Show all
Enzymes
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0010573 [vascular endothelial growth factor production]
GO:0016485 [protein processing]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032964 [collagen biosynthetic process]
GO:0043206 [extracellular fibril organization]
GO:0070062 [extracellular exosome]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
Show all
1205 aa
135.6 kDa
Yes 0

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