A majority of cancer tissues displayed moderate cytoplasmic and nuclear positivity. A few cases of melanomas, colorectal and ovarian cancers displayed strong positivity. A few cases of lymphoma were weakly stained or negative.
A majority of cancer tissues showed weak to moderate cytoplasmic and nuclear positivity. Several cases of breast cancers displayed strong cytoplasmic positivity. Several cases of lymphomas were negative.
ADAMTS3 (HGNC Symbol)
ADAM metallopeptidase with thrombospondin type 1 motif, 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]