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ADAMTS3

GENERAL INFORMATION

Gene name

 ADAMTS3

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 3

Protein class

 Cancer-related genes
Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Mixed
FANTOM5:Tissue enhanced (caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA021368 , HPA021369
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION

Gene name

 ADAMTS3 (HGNC Symbol)

Synonyms

 ADAMTS-4, KIAA0366

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q13.3

Chromosome location (bp)

 72280969 - 72568799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156140 (version 83.38)

Entrez gene

 9508

UniProt

 O15072 (UniProt - Evidence at transcript level)

neXtProt

 NX_O15072

Antibodypedia

 ADAMTS3 antibodies

PROTEIN BROWSER
ADAMTS3-001
ADAMTS3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS3-001
ENSP00000286657
ENST00000286657
O15072 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 3
Show all
Enzymes
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0010573 [vascular endothelial growth factor production]
GO:0016485 [protein processing]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032964 [collagen biosynthetic process]
GO:0043206 [extracellular fibril organization]
GO:0070062 [extracellular exosome]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
Show all
 1205 aa
135.6 kDa 		Yes 0
ADAMTS3-201
ENSP00000480055
ENST00000622135
O15072 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 3
Show all
Enzymes
   Peptidases
   Metallopeptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0004175 [endopeptidase activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0010573 [vascular endothelial growth factor production]
GO:0016485 [protein processing]
GO:0030198 [extracellular matrix organization]
GO:0030199 [collagen fibril organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0032964 [collagen biosynthetic process]
GO:0043206 [extracellular fibril organization]
GO:0070062 [extracellular exosome]
GO:1900748 [positive regulation of vascular endothelial growth factor signaling pathway]
Show all
 1205 aa
135.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.