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CCT8

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GENERAL INFORMATION

Gene name

 CCT8

Gene description

 Chaperonin containing TCP1, subunit 8 (theta)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the intermediate filaments. In addition localized to the nucleus & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Intermediate filaments (supported)

Additional location

 In addition localized to the Nucleus (approved), Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA021051 , HPA029426
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the intermediate filaments. In addition localized to the nucleus & cytosol.

Main location

 Intermediate filaments (supported)

Additional location

 Nucleus (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA021051 RH-30 Nucleus
HPA021051 U-2 OS Intermediate filaments
HPA021051 U-251 MG No staining    
HPA029426 A-431 Nucleoplasm
Cytosol Intensity
HPA029426 U-2 OS Intermediate filaments
Cytosol
HPA029426 U-251 MG Intermediate filaments
Cytosol

GENE INFORMATION

Gene name

 CCT8 (HGNC Symbol)

Synonyms

 C21orf112, Cctq, PRED71

Description

 Chaperonin containing TCP1, subunit 8 (theta) (HGNC Symbol)

Entrez gene summary

 This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 29055805 - 29073797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156261 (version 83.38)

Entrez gene

 10694

UniProt

 P50990 (UniProt - Evidence at protein level)

neXtProt

 NX_P50990

Antibodypedia

 CCT8 antibodies

PROTEIN BROWSER
CCT8-001
CCT8-003
CCT8-006
CCT8-012
CCT8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT8-001
ENSP00000407748
ENST00000432178
H7C2U0 [Direct mapping]
T-complex protein 1 subunit theta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
Show all
 107 aa
11.4 kDa 		No 0
CCT8-003
ENSP00000286788
ENST00000286788
P50990 [Direct mapping]
T-complex protein 1 subunit theta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002199 [zona pellucida receptor complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007339 [binding of sperm to zona pellucida]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046931 [pore complex assembly]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
Show all
 548 aa
59.6 kDa 		No 0
CCT8-006
ENSP00000416832
ENST00000431234
H7C4C8 [Direct mapping]
T-complex protein 1 subunit theta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
Show all
 323 aa
35.4 kDa 		No 0
CCT8-012
ENSP00000486921
ENST00000626972
P50990 [Direct mapping]
T-complex protein 1 subunit theta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
Show all
 529 aa
57.6 kDa 		No 0
CCT8-201
ENSP00000442730
ENST00000540844
P50990 [Direct mapping]
T-complex protein 1 subunit theta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
Show all
 475 aa
51.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.