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CCT8

GENERAL INFORMATION

Gene name

 CCT8

Gene description

 Chaperonin containing TCP1, subunit 8 (theta)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA018520 , HPA021051 , HPA029426
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018520
HPA021051
HPA029426

GENE INFORMATION

Gene name

 CCT8 (HGNC Symbol)

Synonyms

 C21orf112, Cctq, PRED71

Description

 Chaperonin containing TCP1, subunit 8 (theta) (HGNC Symbol)

Entrez gene summary

 This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 29055805 - 29073797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156261 (version 83.38)

Entrez gene

 10694

UniProt

 P50990 (UniProt - Evidence at protein level)

neXtProt

 NX_P50990

Antibodypedia

 CCT8 antibodies

PROTEIN BROWSER
CCT8-001
CCT8-003
CCT8-006
CCT8-012
CCT8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCT8-001
ENSP00000407748
ENST00000432178
H7C2U0 [Direct mapping]
T-complex protein 1 subunit theta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
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 107 aa
11.4 kDa 		No 0
CCT8-003
ENSP00000286788
ENST00000286788
P50990 [Direct mapping]
T-complex protein 1 subunit theta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002199 [zona pellucida receptor complex]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007339 [binding of sperm to zona pellucida]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0044297 [cell body]
GO:0045111 [intermediate filament cytoskeleton]
GO:0046931 [pore complex assembly]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
GO:1901998 [toxin transport]
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 548 aa
59.6 kDa 		No 0
CCT8-006
ENSP00000416832
ENST00000431234
H7C4C8 [Direct mapping]
T-complex protein 1 subunit theta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005524 [ATP binding]
GO:0006457 [protein folding]
GO:0051082 [unfolded protein binding]
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 323 aa
35.4 kDa 		No 0
CCT8-012
ENSP00000486921
ENST00000626972
P50990 [Direct mapping]
T-complex protein 1 subunit theta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 529 aa
57.6 kDa 		No 0
CCT8-201
ENSP00000442730
ENST00000540844
P50990 [Direct mapping]
T-complex protein 1 subunit theta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005832 [chaperonin-containing T-complex]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0016235 [aggresome]
GO:0042623 [ATPase activity, coupled]
GO:0044267 [cellular protein metabolic process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051082 [unfolded protein binding]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0070062 [extracellular exosome]
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 475 aa
51.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.