Cell atlas - BACH1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BACH1
Gene description	BTB and CNC homology 1, basic leucine zipper transcription factor 1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA034949
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA034949	A-431	Nucleoplasm
HPA034949	U-251 MG	Nucleus	Spatial
HPA034949	U-251 MG	Cytosol	Spatial

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000025612 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA034949	NIH 3T3	No staining

GENE INFORMATION
Gene name	BACH1 (HGNC Symbol)
Synonyms	BACH-1, BTBD24
Description	BTB and CNC homology 1, basic leucine zipper transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Chromosome	21
Cytoband	q21.3
Chromosome location (bp)	29194071 - 29630751
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156273 (version 83.38)
Entrez gene	571
UniProt	O14867 (UniProt - Evidence at protein level)
neXtProt	NX_O14867
Antibodypedia	BACH1 antibodies

PROTEIN BROWSER

BACH1-001	BACH1-002	BACH1-003	BACH1-004	BACH1-005	BACH1-006	BACH1-007	BACH1-009	BACH1-010	BACH1-011	BACH1-012	BACH1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BACH1-001 ENSP00000286800 ENST00000286800	O14867 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000117 [regulation of transcription involved in G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0016567 [protein ubiquitination] GO:0020037 [heme binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0043565 [sequence-specific DNA binding] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] Show all	736 aa 82 kDa	No	0
BACH1-002 ENSP00000382805 ENST00000399921	O14867 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000117 [regulation of transcription involved in G2/M transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006281 [DNA repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0016567 [protein ubiquitination] GO:0020037 [heme binding] GO:0031463 [Cul3-RING ubiquitin ligase complex] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] Show all	736 aa 82 kDa	No	0
BACH1-003 ENSP00000392202 ENST00000435072	C9IYH8 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	170 aa 19.4 kDa	No	0
BACH1-004 ENSP00000400576 ENST00000451655	C9IYR0 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] Show all	225 aa 25.5 kDa	No	0
BACH1-005 ENSP00000408605 ENST00000447177	C9JMP6 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] Show all	220 aa 25 kDa	No	0
BACH1-006 ENSP00000416569 ENST00000422809	H7C4B6 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	218 aa 24.5 kDa	No	0
BACH1-007 ENSP00000470673 ENST00000468059	M0QZP0 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	138 aa 15.6 kDa	No	0
BACH1-009 ENSP00000448982 ENST00000548467	F8VZL7 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
BACH1-010 ENSP00000447332 ENST00000548219	F8VZL7 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
BACH1-011 ENSP00000449316 ENST00000550131	F8VZL7 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
BACH1-012 ENSP00000448663 ENST00000547141	F8VZL7 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0
BACH1-013 ENSP00000449383 ENST00000546469	F8VZL7 [Direct mapping] Transcription regulator protein BACH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.7 kDa	No	0