Expression of CDK20 in cancer - Summary - The Human Protein Atlas

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CDK20

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDK20
Gene description	Cyclin-dependent kinase 20
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H, THP-1)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues. Expression in fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA007666 , HPA027379 , HPA027401
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007666	HPA027379	HPA027401

GENE INFORMATION
Gene name	CDK20 (HGNC Symbol)
Synonyms	CCRK, p42
Description	Cyclin-dependent kinase 20 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
Chromosome	9
Cytoband	q22.1
Chromosome location (bp)	87966441 - 87974753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156345 (version 83.38)
Entrez gene	23552
UniProt	Q8IZL9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZL9
Antibodypedia	CDK20 antibodies

PROTEIN BROWSER

CDK20-001	CDK20-004	CDK20-005	CDK20-006	CDK20-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK20-001 ENSP00000365043 ENST00000375883	Q8IZL9 [Direct mapping] Cyclin-dependent kinase 20 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007275 [multicellular organismal development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	325 aa 36.1 kDa	No	0
CDK20-004 ENSP00000322343 ENST00000325303	Q8IZL9 [Direct mapping] Cyclin-dependent kinase 20 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007275 [multicellular organismal development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	346 aa 38.7 kDa	No	0
CDK20-005 ENSP00000338975 ENST00000336654	Q8IZL9 [Direct mapping] Cyclin-dependent kinase 20 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007275 [multicellular organismal development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	338 aa 37.6 kDa	No	0
CDK20-006 ENSP00000365031 ENST00000375871	Q8IZL9 [Direct mapping] Cyclin-dependent kinase 20 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007275 [multicellular organismal development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	243 aa 27.1 kDa	No	0
CDK20-012 ENSP00000474485 ENST00000605159	Q8IZL9 [Direct mapping] Cyclin-dependent kinase 20 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005929 [cilium] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007275 [multicellular organismal development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	275 aa 30.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.