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MAPK13

GENERAL INFORMATION

Gene name

 MAPK13

Gene description

 Mitogen-activated protein kinase 13

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA007667 , CAB025854
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007667
CAB025854

GENE INFORMATION

Gene name

 MAPK13 (HGNC Symbol)

Synonyms

 p38delta, PRKM13, SAPK4

Description

 Mitogen-activated protein kinase 13 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 36127809 - 36144524

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156711 (version 83.38)

Entrez gene

 5603

UniProt

 O15264 (UniProt - Evidence at protein level)

neXtProt

 NX_O15264

Antibodypedia

 MAPK13 antibodies

PROTEIN BROWSER
MAPK13-001
MAPK13-004
MAPK13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK13-001
ENSP00000211287
ENST00000211287
O15264 [Direct mapping]
Mitogen-activated protein kinase 13
A0A024RD04 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0006970 [response to osmotic stress]
GO:0007049 [cell cycle]
GO:0007265 [Ras protein signal transduction]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0035556 [intracellular signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050729 [positive regulation of inflammatory response]
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 365 aa
42.1 kDa 		No 0
MAPK13-004
ENSP00000362864
ENST00000373759
Q5R3E6 [Direct mapping]
Mitogen-activated protein kinase 13
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 152 aa
17.3 kDa 		No 0
MAPK13-201
ENSP00000362871
ENST00000373766
O15264 [Direct mapping]
Mitogen-activated protein kinase 13
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0006970 [response to osmotic stress]
GO:0007049 [cell cycle]
GO:0007265 [Ras protein signal transduction]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0035556 [intracellular signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050729 [positive regulation of inflammatory response]
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 257 aa
28.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.