Expression of MS4A1 in cancer - Summary - The Human Protein Atlas

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MS4A1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MS4A1
Gene description	Membrane-spanning 4-domains, subfamily A, member 1
Protein class	CD markers Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Daudi, U-698)
HPA (normal tissue):	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous and cytoplasmic expression in leukocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA014341 , HPA014391 , CAB000015
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014341	HPA014391	CAB000015

GENE INFORMATION
Gene name	MS4A1 (HGNC Symbol)
Synonyms	B1, Bp35, CD20, MS4A2
Description	Membrane-spanning 4-domains, subfamily A, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60455752 - 60470760
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000156738 (version 83.38)
Entrez gene	931
UniProt	P11836 (UniProt - Evidence at protein level)
neXtProt	NX_P11836
Antibodypedia	MS4A1 antibodies

PROTEIN BROWSER

MS4A1-001	MS4A1-002	MS4A1-003	MS4A1-006	MS4A1-007	MS4A1-008	MS4A1-201	MS4A1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MS4A1-001 ENSP00000433277 ENST00000534668	P11836 [Direct mapping] B-lymphocyte antigen CD20 A0A024R507 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a Show all	CD markers Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005154 [epidermal growth factor receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006959 [humoral immune response] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0023026 [MHC class II protein complex binding] GO:0042100 [B cell proliferation] GO:0070062 [extracellular exosome] Show all	297 aa 33.1 kDa	No	5
MS4A1-002 ENSP00000433519 ENST00000532073	E9PKH8 [Direct mapping] B-lymphocyte antigen CD20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	284 aa 31.6 kDa	No	3
MS4A1-003 ENSP00000432270 ENST00000528313	P11836 [Direct mapping] B-lymphocyte antigen CD20 Show all	CD markers Transporters Transporter channels and pores Predicted intracellular proteins Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006959 [humoral immune response] GO:0023026 [MHC class II protein complex binding] GO:0042100 [B cell proliferation] GO:0070062 [extracellular exosome] Show all	130 aa 14.6 kDa	No	0
MS4A1-006 ENSP00000437002 ENST00000533306	E9PPL6 [Direct mapping] B-lymphocyte antigen CD20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	123 aa 13.7 kDa	No	2
MS4A1-007 ENSP00000433179 ENST00000524807		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.8 kDa	No	0
MS4A1-008 ENSP00000432219 ENST00000532491		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
MS4A1-201 ENSP00000314620 ENST00000345732	P11836 [Direct mapping] B-lymphocyte antigen CD20 A0A024R507 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a Show all	CD markers Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006959 [humoral immune response] GO:0016021 [integral component of membrane] GO:0023026 [MHC class II protein complex binding] GO:0042100 [B cell proliferation] GO:0070062 [extracellular exosome] Show all	297 aa 33.1 kDa	No	5
MS4A1-202 ENSP00000374589 ENST00000389939	P11836 [Direct mapping] B-lymphocyte antigen CD20 A0A024R507 [Target identity:100%; Query identity:100%] Membrane-spanning 4-domains, subfamily A, member 1, isoform CRA_a Show all	CD markers Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005887 [integral component of plasma membrane] GO:0006959 [humoral immune response] GO:0016021 [integral component of membrane] GO:0023026 [MHC class II protein complex binding] GO:0042100 [B cell proliferation] GO:0070062 [extracellular exosome] Show all	297 aa 33.1 kDa	No	5

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