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ATAD2

GENERAL INFORMATION

Gene name

 ATAD2

Gene description

 ATPase family, AAA domain containing 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in proliferating cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA029424 , CAB056158
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029424
CAB056158

GENE INFORMATION

Gene name

 ATAD2 (HGNC Symbol)

Synonyms

 CT137, DKFZp667N1320, MGC29843, MGC5254, PRO2000

Description

 ATPase family, AAA domain containing 2 (HGNC Symbol)

Entrez gene summary

 A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.13

Chromosome location (bp)

 123319850 - 123416350

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156802 (version 83.38)

Entrez gene

 29028

UniProt

 Q6PL18 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6PL18

Antibodypedia

 ATAD2 antibodies

PROTEIN BROWSER
ATAD2-001
ATAD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATAD2-001
ENSP00000287394
ENST00000287394
Q6PL18 [Direct mapping]
ATPase family AAA domain-containing protein 2
A0A024R9G7 [Target identity:100%; Query identity:100%]
ATPase family, AAA domain containing 2, isoform CRA_c
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0016887 [ATPase activity]
GO:0031936 [negative regulation of chromatin silencing]
GO:0042393 [histone binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
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 1390 aa
158.6 kDa 		No 0
ATAD2-002
ENSP00000429213
ENST00000521903
A0A0B4J211 [Direct mapping]
ATPase family AAA domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0031936 [negative regulation of chromatin silencing]
GO:0042393 [histone binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 708 aa
80.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.