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BUB1B

GENERAL INFORMATION

Gene name

 BUB1B

Gene description

 BUB1 mitotic checkpoint serine/threonine kinase B

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 BUB1B (HGNC Symbol)

Synonyms

 Bub1A, BUBR1, MAD3L, SSK1

Description

 BUB1 mitotic checkpoint serine/threonine kinase B (HGNC Symbol)

Entrez gene summary

 This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40161023 - 40221136

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000156970 (version 83.38)

Entrez gene

 701

UniProt

 O60566 (UniProt - Evidence at protein level)

neXtProt

 NX_O60566

Antibodypedia

 BUB1B antibodies

PROTEIN BROWSER
BUB1B-001
BUB1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BUB1B-001
ENSP00000287598
ENST00000287598
O60566 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000778 [condensed nuclear chromosome kinetochore]
GO:0000940 [condensed chromosome outer kinetochore]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0007091 [metaphase/anaphase transition of mitotic cell cycle]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0071459 [protein localization to chromosome, centromeric region]
Show all
 1050 aa
119.5 kDa 		No 0
BUB1B-003
ENSP00000398470
ENST00000412359
O60566 [Direct mapping]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000940 [condensed chromosome outer kinetochore]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005680 [anaphase-promoting complex]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007067 [mitotic nuclear division]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008283 [cell proliferation]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0034501 [protein localization to kinetochore]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
Show all
 1064 aa
121.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.