Cell atlas - CPT2 - The Human Protein Atlas

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CPT2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoli
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CPT2
Gene description	Carnitine palmitoyltransferase 2
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli, mitochondria & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (uncertain), Nucleoli (uncertain), Mitochondria (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028214
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli, mitochondria & nucleoplasm.

Main location

Nucleoplasm (uncertain), Nucleoli (uncertain), Mitochondria (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028214	A-431	Nucleoplasm
			Nucleoli	Intensity
			Mitochondria
	HPA028214	U-2 OS	Nucleoplasm
	HPA028214	U-2 OS	Mitochondria
	HPA028214	U-251 MG	Nucleoplasm
	HPA028214	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	CPT2 (HGNC Symbol)
Synonyms	CPT1, CPTASE
Description	Carnitine palmitoyltransferase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p32.3
Chromosome location (bp)	53196429 - 53214197
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157184 (version 83.38)
Entrez gene	1376
UniProt	P23786 (UniProt - Evidence at protein level)
neXtProt	NX_P23786
Antibodypedia	CPT2 antibodies

PROTEIN BROWSER

CPT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPT2-001 ENSP00000360541 ENST00000371486	P23786 [Direct mapping] Carnitine O-palmitoyltransferase 2, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006635 [fatty acid beta-oxidation] GO:0006853 [carnitine shuttle] GO:0016746 [transferase activity, transferring acyl groups] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	658 aa 73.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.