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CPT2

GENERAL INFORMATION

Gene name

 CPT2

Gene description

 Carnitine palmitoyltransferase 2

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA028201 , HPA028202 , HPA028214
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028201
HPA028202
HPA028214

GENE INFORMATION

Gene name

 CPT2 (HGNC Symbol)

Synonyms

 CPT1, CPTASE

Description

 Carnitine palmitoyltransferase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear protein which is transported to the mitochondrial inner membrane. Together with carnitine palmitoyltransferase I, the encoded protein oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p32.3

Chromosome location (bp)

 53196429 - 53214197

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157184 (version 83.38)

Entrez gene

 1376

UniProt

 P23786 (UniProt - Evidence at protein level)

neXtProt

 NX_P23786

Antibodypedia

 CPT2 antibodies

PROTEIN BROWSER
CPT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CPT2-001
ENSP00000360541
ENST00000371486
P23786 [Direct mapping]
Carnitine O-palmitoyltransferase 2, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004095 [carnitine O-palmitoyltransferase activity]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006635 [fatty acid beta-oxidation]
GO:0006853 [carnitine shuttle]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 658 aa
73.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.