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Testicular cancers showed strong nuclear staining in most cases. Urothelial, cervical and a few cases in several cancers displayed moderate to strong nuclear staining. Most cases of renal, pancreatic, liver, lung and prostate cancers were negative.
GENE INFORMATION
Gene name
PAXIP1 (HGNC Symbol)
Synonyms
CAGF28, CAGF29, PAXIP1L, PTIP, TNRC2
Description
PAX interacting (with transcription-activation domain) protein 1 (HGNC Symbol)
Entrez gene summary
This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]