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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MMP14
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MMP14

Gene description

Matrix metallopeptidase 14 (membrane-inserted)

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-138 MG)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA051432 , CAB009918
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Ovarian cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA051432
CAB009918

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity was observed in several pancreatic cancers and papillary adenocarcinomas of thyroid along with few melanomas, colorectal, ovarian, stomach, renal and prostate cancers. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of renal cancers were moderately stained. Most remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

MMP14 (HGNC Symbol)

Synonyms

MT1-MMP

Description

Matrix metallopeptidase 14 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

22836557 - 22849027

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157227 (version 83.38)

Entrez gene

4323

UniProt

P50281 (UniProt - Evidence at protein level)

neXtProt

NX_P50281

Antibodypedia

MMP14 antibodies

PROTEIN BROWSER

MMP14-001
MMP14-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP14-001
ENSP00000308208
ENST00000311852
P50281 [Direct mapping]
Matrix metalloproteinase-14
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001525 [angiogenesis]
GO:0001541 [ovarian follicle development]
GO:0001666 [response to hypoxia]
GO:0001935 [endothelial cell proliferation]
GO:0001958 [endochondral ossification]
GO:0004222 [metalloendopeptidase activity]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0006979 [response to oxidative stress]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0010831 [positive regulation of myotube differentiation]
GO:0010952 [positive regulation of peptidase activity]
GO:0014070 [response to organic cyclic compound]
GO:0016477 [cell migration]
GO:0016504 [peptidase activator activity]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030307 [positive regulation of cell growth]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0031410 [cytoplasmic vesicle]
GO:0031638 [zymogen activation]
GO:0035987 [endodermal cell differentiation]
GO:0035988 [chondrocyte proliferation]
GO:0042470 [melanosome]
GO:0043615 [astrocyte cell migration]
GO:0043627 [response to estrogen]
GO:0044354 [macropinosome]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048771 [tissue remodeling]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0060348 [bone development]
GO:0097094 [craniofacial suture morphogenesis]
Show all
582 aa
65.9 kDa
Yes 1
MMP14-007
ENSP00000446989
ENST00000548761
F8W1B7 [Direct mapping]
Matrix metalloproteinase-14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0031012 [extracellular matrix]
Show all
194 aa
22.3 kDa
Yes 0

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