Cell atlas - CCNB2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CCNB2

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus

Human cell
	Cytosol
	Golgi Apparatus

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CCNB2
Gene description	Cyclin B2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)
Additional location	In addition localized to the Golgi apparatus (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA008873 , CAB009575
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the Golgi apparatus.

Main location

Cytosol (validated)

Additional location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008873	A-431	Cytosol	Intensity
	HPA008873	U-2 OS	Cytosol	Intensity
	HPA008873	U-251 MG	Cytosol	Intensity
	CAB009575	A-431	Cytosol	Intensity
	CAB009575	U-2 OS	Golgi apparatus
	CAB009575	U-2 OS	Cytosol	Intensity	Intensity
	CAB009575	U-251 MG	Golgi apparatus
	CAB009575	U-251 MG	Cytosol	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis
Intensity variation	Cytosol
CAB009575

GENE INFORMATION
Gene name	CCNB2 (HGNC Symbol)
Synonyms	HsT17299
Description	Cyclin B2 (HGNC Symbol)
Entrez gene summary	Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	59105078 - 59125045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157456 (version 83.38)
Entrez gene	9133
UniProt	O95067 (UniProt - Evidence at protein level)
neXtProt	NX_O95067
Antibodypedia	CCNB2 antibodies

PROTEIN BROWSER

CCNB2-001	CCNB2-002	CCNB2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNB2-001 ENSP00000288207 ENST00000288207	O95067 [Direct mapping] G2/mitotic-specific cyclin-B2 Show all	Transporters Transporter channels and pores SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0001701 [in utero embryonic development] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0040007 [growth] GO:0043029 [T cell homeostasis] GO:0048538 [thymus development] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	398 aa 45.3 kDa	No	0
CCNB2-002 ENSP00000453685 ENST00000559622	H0YMP3 [Direct mapping] G2/mitotic-specific cyclin-B2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	270 aa 31.2 kDa	No	0
CCNB2-201 ENSP00000480809 ENST00000621385	H1UBN3 [Direct mapping] Cyclin B2; G2/mitotic-specific cyclin-B2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	374 aa 42.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.