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CCNB2

GENERAL INFORMATION

Gene name

 CCNB2

Gene description

 Cyclin B2

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA008873 , CAB009575
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), melanoma (unfavourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Melanoma p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA008873
CAB009575

GENE INFORMATION

Gene name

 CCNB2 (HGNC Symbol)

Synonyms

 HsT17299

Description

 Cyclin B2 (HGNC Symbol)

Entrez gene summary

 Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 59105078 - 59125045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157456 (version 83.38)

Entrez gene

 9133

UniProt

 O95067 (UniProt - Evidence at protein level)

neXtProt

 NX_O95067

Antibodypedia

 CCNB2 antibodies

PROTEIN BROWSER
CCNB2-001
CCNB2-002
CCNB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCNB2-001
ENSP00000288207
ENST00000288207
O95067 [Direct mapping]
G2/mitotic-specific cyclin-B2
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0015630 [microtubule cytoskeleton]
GO:0016020 [membrane]
GO:0040007 [growth]
GO:0043029 [T cell homeostasis]
GO:0048538 [thymus development]
GO:0051301 [cell division]
GO:0051726 [regulation of cell cycle]
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 398 aa
45.3 kDa 		No 0
CCNB2-002
ENSP00000453685
ENST00000559622
H0YMP3 [Direct mapping]
G2/mitotic-specific cyclin-B2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 270 aa
31.2 kDa 		No 0
CCNB2-201
ENSP00000480809
ENST00000621385
H1UBN3 [Direct mapping]
Cyclin B2; G2/mitotic-specific cyclin-B2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 374 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.