Tissue expression of ETS2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ETS2
Gene description	V-ets avian erythroblastosis virus E26 oncogene homolog 2
Protein class	Predicted intracellular proteins RAS pathway related proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ETS2
Synonyms
Description	V-ets avian erythroblastosis virus E26 oncogene homolog 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	21
Cytoband	q22.2
Chromosome location (bp)	38805307 - 38824955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157557 (version 83.38)
Entrez gene	2114
UniProt	P15036 (UniProt - Evidence at protein level)
neXtProt	NX_P15036
Antibodypedia	ETS2 antibodies

PROTEIN BROWSER

ETS2-001	ETS2-002	ETS2-003	ETS2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETS2-001 ENSP00000353344 ENST00000360214	P15036 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0001712 [ectodermal cell fate commitment] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0030154 [cell differentiation] GO:0035259 [glucocorticoid receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0090009 [primitive streak formation] Show all	469 aa 53 kDa	No	0
ETS2-002 ENSP00000354194 ENST00000360938	P15036 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	469 aa 53 kDa	No	0
ETS2-003 ENSP00000401273 ENST00000432278	A0A0C4DG47 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	168 aa 19.1 kDa	No	0
ETS2-004 ENSP00000411086 ENST00000456966	C9JAG2 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	270 aa 30.4 kDa	No	0