Cell atlas - ETS2 - The Human Protein Atlas

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ETS2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ETS2
Gene description	V-ets avian erythroblastosis virus E26 oncogene homolog 2
Protein class	Predicted intracellular proteins RAS pathway related proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Plasma membrane (uncertain)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA003176
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

Nucleoplasm (supported)

Additional location

Plasma membrane (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003176	A-431	Nucleoplasm
	HPA003176	SiHa	Nucleoplasm
	HPA003176	U-2 OS	Plasma membrane
	HPA003176	U-2 OS	Cytosol

GFP

Antibody	HPA003176
Validation	C-terminal tag BAC cell line: 5628 Validated: Antibody staining overlaps with GFP tagged protein but show additional locations


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA003176	HeLa	5628	C-terminal	Nucleoplasm, Plasma membrane	Nucleoplasm
	HPA003176	HeLa	Normal	-	Plasma membrane	-

GENE INFORMATION
Gene name	ETS2
Synonyms
Description	V-ets avian erythroblastosis virus E26 oncogene homolog 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	21
Cytoband	q22.2
Chromosome location (bp)	38805307 - 38824955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157557 (version 83.38)
Entrez gene	2114
UniProt	P15036 (UniProt - Evidence at protein level)
neXtProt	NX_P15036
Antibodypedia	ETS2 antibodies

PROTEIN BROWSER

ETS2-001	ETS2-002	ETS2-003	ETS2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ETS2-001 ENSP00000353344 ENST00000360214	P15036 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0001712 [ectodermal cell fate commitment] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007498 [mesoderm development] GO:0030154 [cell differentiation] GO:0035259 [glucocorticoid receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0090009 [primitive streak formation] Show all	469 aa 53 kDa	No	0
ETS2-002 ENSP00000354194 ENST00000360938	P15036 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001501 [skeletal system development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	469 aa 53 kDa	No	0
ETS2-003 ENSP00000401273 ENST00000432278	A0A0C4DG47 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	168 aa 19.1 kDa	No	0
ETS2-004 ENSP00000411086 ENST00000456966	C9JAG2 [Direct mapping] Protein C-ets-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] Show all	270 aa 30.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.