Fields »
ABOUT
HELP
BLOG
MX1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 MX1

Gene description

 MX dynamin-like GTPase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear membrane & cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear membrane (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA049724
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear membrane & cytosol.

Main location

 Nuclear membrane (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049724 A-431 Nuclear membrane
Cytosol
HPA049724 PC-3 Nuclear membrane
Cytosol
HPA049724 U-2 OS Nuclear membrane Intensity
Cytosol

GENE INFORMATION

Gene name

 MX1 (HGNC Symbol)

Synonyms

 IFI-78K, MxA

Description

 MX dynamin-like GTPase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 41420304 - 41459214

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157601 (version 83.38)

Entrez gene

 4599

UniProt

 P20591 (UniProt - Evidence at protein level)

neXtProt

 NX_P20591

Antibodypedia

 MX1 antibodies

PROTEIN BROWSER
«
MX1-001
MX1-002
MX1-003
MX1-007
MX1-008
MX1-009
MX1-010
MX1-012
MX1-013
MX1-201
MX1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MX1-001
ENSP00000381601
ENST00000398600
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 662 aa
75.5 kDa 		No 0
MX1-002
ENSP00000381599
ENST00000398598
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 662 aa
75.5 kDa 		No 0
MX1-003
ENSP00000288383
ENST00000288383
F8W8T1 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0031965 [nuclear membrane]
Show all
 639 aa
73.3 kDa 		No 0
MX1-007
ENSP00000408498
ENST00000413778
H9KVD0 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 68 aa
7.2 kDa 		No 0
MX1-008
ENSP00000392151
ENST00000419044
H9KVC3 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 26 aa
2.6 kDa 		No 0
MX1-009
ENSP00000400923
ENST00000424365
H9KVC7 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 197 aa
20.9 kDa 		No 0
MX1-010
ENSP00000402215
ENST00000417963
H9KVC9 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 201 aa
21.4 kDa 		No 0
MX1-012
ENSP00000393931
ENST00000441677
H9KVC4 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 77 aa
8 kDa 		No 0
MX1-013
ENSP00000410989
ENST00000427464
H9KVD3 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
3.5 kDa 		No 0
MX1-201
ENSP00000410523
ENST00000455164
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 662 aa
75.5 kDa 		No 0
MX1-202
ENSP00000478441
ENST00000619682
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 508 aa
55.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.