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MX1

GENERAL INFORMATION

Gene name

 MX1

Gene description

 MX dynamin-like GTPase 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030917
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030917

GENE INFORMATION

Gene name

 MX1 (HGNC Symbol)

Synonyms

 IFI-78K, MxA

Description

 MX dynamin-like GTPase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 41420304 - 41459214

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157601 (version 83.38)

Entrez gene

 4599

UniProt

 P20591 (UniProt - Evidence at protein level)

neXtProt

 NX_P20591

Antibodypedia

 MX1 antibodies

PROTEIN BROWSER
«
MX1-001
MX1-002
MX1-003
MX1-007
MX1-008
MX1-009
MX1-010
MX1-012
MX1-013
MX1-201
MX1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MX1-001
ENSP00000381601
ENST00000398600
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 662 aa
75.5 kDa 		No 0
MX1-002
ENSP00000381599
ENST00000398598
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
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 662 aa
75.5 kDa 		No 0
MX1-003
ENSP00000288383
ENST00000288383
F8W8T1 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0008152 [metabolic process]
GO:0031965 [nuclear membrane]
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 639 aa
73.3 kDa 		No 0
MX1-007
ENSP00000408498
ENST00000413778
H9KVD0 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 68 aa
7.2 kDa 		No 0
MX1-008
ENSP00000392151
ENST00000419044
H9KVC3 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 26 aa
2.6 kDa 		No 0
MX1-009
ENSP00000400923
ENST00000424365
H9KVC7 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 197 aa
20.9 kDa 		No 0
MX1-010
ENSP00000402215
ENST00000417963
H9KVC9 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
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 201 aa
21.4 kDa 		No 0
MX1-012
ENSP00000393931
ENST00000441677
H9KVC4 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 77 aa
8 kDa 		No 0
MX1-013
ENSP00000410989
ENST00000427464
H9KVD3 [Direct mapping]
Interferon-induced GTP-binding protein Mx1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 35 aa
3.5 kDa 		No 0
MX1-201
ENSP00000410523
ENST00000455164
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 662 aa
75.5 kDa 		No 0
MX1-202
ENSP00000478441
ENST00000619682
P20591 [Direct mapping]
Interferon-induced GTP-binding protein Mx1 Interferon-induced GTP-binding protein Mx1, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0009615 [response to virus]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031965 [nuclear membrane]
GO:0034340 [response to type I interferon]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051607 [defense response to virus]
GO:0060337 [type I interferon signaling pathway]
Show all
 508 aa
55.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.