Expression of C2CD2 in cancer - Summary - The Human Protein Atlas

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C2CD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C2CD2
Gene description	C2 calcium-dependent domain containing 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (adrenal gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in adrenal gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA030922 , HPA030924
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030922	HPA030924

GENE INFORMATION
Gene name	C2CD2 (HGNC Symbol)
Synonyms	C21orf25, C21orf258, DKFZP586F0422, TMEM24L
Description	C2 calcium-dependent domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	41885112 - 41953890
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157617 (version 83.38)
Entrez gene	25966
UniProt	Q9Y426 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y426
Antibodypedia	C2CD2 antibodies

PROTEIN BROWSER

C2CD2-001	C2CD2-002	C2CD2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C2CD2-001 ENSP00000369853 ENST00000380486	Q9Y426 [Direct mapping] C2 domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] Show all	696 aa 75.5 kDa	Yes	0
C2CD2-002 ENSP00000329302 ENST00000329623	Q9Y426 [Direct mapping] C2 domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005829 [cytosol] Show all	541 aa 58.6 kDa	No	0
C2CD2-006 ENSP00000388704 ENST00000449165	H7BZB0 [Direct mapping] C2 domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		182 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.