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DPYSL5

GENERAL INFORMATION

Gene name

 DPYSL5

Gene description

 Dihydropyrimidinase-like 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, testis)
GTEx:Tissue enhanced (caudate, cerebellum, hypothalamus)
FANTOM5:Tissue enhanced (brain, caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. GTEX supports antibody staining in CNS.

Reliability score

 Supported based on 1 antibody.
HPA034544
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, caudate, cerebellum)

GENE INFORMATION

Gene name

 DPYSL5 (HGNC Symbol)

Synonyms

 CRAM, CRMP-5, CRMP5, Ulip6

Description

 Dihydropyrimidinase-like 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 26847747 - 26950351

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000157851 (version 83.38)

Entrez gene

 56896

UniProt

 Q9BPU6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BPU6

Antibodypedia

 DPYSL5 antibodies

PROTEIN BROWSER
DPYSL5-001
DPYSL5-002
DPYSL5-003
DPYSL5-004
DPYSL5-005
DPYSL5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPYSL5-001
ENSP00000288699
ENST00000288699
Q9BPU6 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0030425 [dendrite]
GO:0043025 [neuronal cell body]
Show all
 564 aa
61.4 kDa 		No 0
DPYSL5-002
ENSP00000385549
ENST00000401478
Q9BPU6 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 564 aa
61.4 kDa 		No 0
DPYSL5-003
ENSP00000407174
ENST00000450961
E9PHT0 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 165 aa
18 kDa 		No 0
DPYSL5-004
ENSP00000399581
ENST00000431402
E7EWB4 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 190 aa
20.9 kDa 		No 0
DPYSL5-005
ENSP00000413075
ENST00000434719
E7ESV0 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 174 aa
19.1 kDa 		No 0
DPYSL5-201
ENSP00000481305
ENST00000614712
Q9BPU6 [Direct mapping]
Dihydropyrimidinase-related protein 5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 564 aa
61.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.