Expression of AGAP1 in cancer - Summary - The Human Protein Atlas

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AGAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGAP1
Gene description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA051405
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (favourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051405

GENE INFORMATION
Gene name	AGAP1 (HGNC Symbol)
Synonyms	CENTG2, GGAP1, KIAA1099
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	2
Cytoband	q37.2
Chromosome location (bp)	235494089 - 236131800
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157985 (version 83.38)
Entrez gene	116987
UniProt	Q9UPQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPQ3
Antibodypedia	AGAP1 antibodies

PROTEIN BROWSER

AGAP1-001	AGAP1-002	AGAP1-003	AGAP1-004	AGAP1-006	AGAP1-007	AGAP1-010	AGAP1-201	AGAP1-202	AGAP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGAP1-001 ENSP00000307634 ENST00000304032	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	857 aa 94.5 kDa	No	0
AGAP1-002 ENSP00000338378 ENST00000336665	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	804 aa 89.1 kDa	No	0
AGAP1-003 ENSP00000387174 ENST00000409457	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	405 aa 44.5 kDa	No	0
AGAP1-004 ENSP00000386897 ENST00000409538	E7EUN2 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	1069 aa 116.6 kDa	No	0
AGAP1-006 ENSP00000385492 ENST00000402604	C9J8Z2 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] Show all	117 aa 13.3 kDa	No	0
AGAP1-007 ENSP00000393838 ENST00000418654	H7C0A7 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	276 aa 30.6 kDa	No	0
AGAP1-010 ENSP00000403482 ENST00000448025	H7C211 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 27.3 kDa	No	0
AGAP1-201 ENSP00000411824 ENST00000428334	F5GXM9 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	803 aa 88.1 kDa	No	0
AGAP1-202 ENSP00000484463 ENST00000614409	A0A087X1U1 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	750 aa 82.7 kDa	No	0
AGAP1-203 ENSP00000483085 ENST00000619456	A0A087X044 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	351 aa 38.1 kDa	No	0

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The Human Protein Atlas

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