Tissue expression of AGAP1 - Summary - The Human Protein Atlas

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AGAP1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AGAP1
Gene description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA051405
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AGAP1 (HGNC Symbol)
Synonyms	CENTG2, GGAP1, KIAA1099
Description	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	2
Cytoband	q37.2
Chromosome location (bp)	235494089 - 236131800
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000157985 (version 83.38)
Entrez gene	116987
UniProt	Q9UPQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPQ3
Antibodypedia	AGAP1 antibodies

PROTEIN BROWSER

AGAP1-001	AGAP1-002	AGAP1-003	AGAP1-004	AGAP1-006	AGAP1-007	AGAP1-010	AGAP1-201	AGAP1-202	AGAP1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGAP1-001 ENSP00000307634 ENST00000304032	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	857 aa 94.5 kDa	No	0
AGAP1-002 ENSP00000338378 ENST00000336665	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	804 aa 89.1 kDa	No	0
AGAP1-003 ENSP00000387174 ENST00000409457	Q9UPQ3 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005525 [GTP binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	405 aa 44.5 kDa	No	0
AGAP1-004 ENSP00000386897 ENST00000409538	E7EUN2 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	1069 aa 116.6 kDa	No	0
AGAP1-006 ENSP00000385492 ENST00000402604	C9J8Z2 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] Show all	117 aa 13.3 kDa	No	0
AGAP1-007 ENSP00000393838 ENST00000418654	H7C0A7 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	276 aa 30.6 kDa	No	0
AGAP1-010 ENSP00000403482 ENST00000448025	H7C211 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		253 aa 27.3 kDa	No	0
AGAP1-201 ENSP00000411824 ENST00000428334	F5GXM9 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	803 aa 88.1 kDa	No	0
AGAP1-202 ENSP00000484463 ENST00000614409	A0A087X1U1 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	750 aa 82.7 kDa	No	0
AGAP1-203 ENSP00000483085 ENST00000619456	A0A087X044 [Direct mapping] Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	351 aa 38.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.