Expression of PAFAH2 in cancer - Summary - The Human Protein Atlas

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PAFAH2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PAFAH2
Gene description	Platelet-activating factor acetylhydrolase 2, 40kDa
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA018157
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018157

GENE INFORMATION
Gene name	PAFAH2 (HGNC Symbol)
Synonyms	HSD-PLA2
Description	Platelet-activating factor acetylhydrolase 2, 40kDa (HGNC Symbol)
Entrez gene summary	This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	25959767 - 25998157
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158006 (version 83.38)
Entrez gene	5051
UniProt	Q99487 (UniProt - Evidence at protein level)
neXtProt	NX_Q99487
Antibodypedia	PAFAH2 antibodies

PROTEIN BROWSER

PAFAH2-001	PAFAH2-003	PAFAH2-004	PAFAH2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAFAH2-001 ENSP00000363400 ENST00000374282	Q99487 [Direct mapping] Platelet-activating factor acetylhydrolase 2, cytoplasmic Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0016042 [lipid catabolic process] GO:0043066 [negative regulation of apoptotic process] Show all	392 aa 44 kDa	No	0
PAFAH2-003 ENSP00000411011 ENST00000441420	Q5SY01 [Direct mapping] Platelet-activating factor acetylhydrolase 2, cytoplasmic Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0016042 [lipid catabolic process] Show all	165 aa 18.5 kDa	No	0
PAFAH2-004 ENSP00000363402 ENST00000374284	Q99487 [Direct mapping] Platelet-activating factor acetylhydrolase 2, cytoplasmic Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0006629 [lipid metabolic process] GO:0016042 [lipid catabolic process] Show all	392 aa 44 kDa	No	0
PAFAH2-005 ENSP00000408313 ENST00000439092	Q5SY00 [Direct mapping] Platelet-activating factor acetylhydrolase 2, cytoplasmic Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003847 [1-alkyl-2-acetylglycerophosphocholine esterase activity] GO:0016042 [lipid catabolic process] Show all	186 aa 21.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.