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EXTL1

GENERAL INFORMATION

Gene name

 EXTL1

Gene description

 Exostosin-like glycosyltransferase 1

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Cell line enriched (WM-115)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA037749
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037749

GENE INFORMATION

Gene name

 EXTL1 (HGNC Symbol)

Synonyms

 EXTL, MGC70794

Description

 Exostosin-like glycosyltransferase 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26019884 - 26036464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158008 (version 83.38)

Entrez gene

 2134

UniProt

 Q92935 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q92935

Antibodypedia

 EXTL1 antibodies

PROTEIN BROWSER
EXTL1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXTL1-001
ENSP00000363398
ENST00000374280
Q92935 [Direct mapping]
Exostosin-like 1
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0001501 [skeletal system development]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0006486 [protein glycosylation]
GO:0015012 [heparan sulfate proteoglycan biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0050508 [glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity]
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 676 aa
74.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.