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Cancer cells were in most cases weakly stained or negative. A few cases of breast, prostate and pancreatic cancer were moderated stained. Breast cancer showed strong immunoreactivity in subsets of cells.
GENE INFORMATION
Gene name
UBXN11 (HGNC Symbol)
Synonyms
SOC, SOCI, UBXD5
Description
UBX domain protein 11 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]