Expression of UBXN11 in cancer - Summary - The Human Protein Atlas

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UBXN11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBXN11
Gene description	UBX domain protein 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA028600
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (favourable), endometrial cancer (favourable) and head and neck cancer (favourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Endometrial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028600

GENE INFORMATION
Gene name	UBXN11 (HGNC Symbol)
Synonyms	SOC, SOCI, UBXD5
Description	UBX domain protein 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	26281328 - 26318363
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158062 (version 83.38)
Entrez gene	91544
UniProt	Q5T124 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T124
Antibodypedia	UBXN11 antibodies

PROTEIN BROWSER

UBXN11-001	UBXN11-002	UBXN11-003	UBXN11-004	UBXN11-008	UBXN11-009	UBXN11-010	UBXN11-011	UBXN11-014	UBXN11-015	UBXN11-016	UBXN11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBXN11-001 ENSP00000363339 ENST00000374222	Q5T124 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	520 aa 57.4 kDa	No	0
UBXN11-002 ENSP00000349601 ENST00000357089	Q5T124 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	487 aa 54 kDa	No	0
UBXN11-003 ENSP00000324721 ENST00000314675	Q5T124 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	400 aa 43.3 kDa	No	0
UBXN11-004 ENSP00000363338 ENST00000374221	Q5T124 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	520 aa 57.4 kDa	No	0
UBXN11-008 ENSP00000363340 ENST00000374223	X6R8M6 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	277 aa 30.1 kDa	No	0
UBXN11-009 ENSP00000413448 ENST00000450041	Q5T118 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	116 aa 13.7 kDa	No	0
UBXN11-010 ENSP00000395165 ENST00000421827	X6RDY0 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	134 aa 14.8 kDa	No	0
UBXN11-011 ENSP00000404956 ENST00000442942	Q5T130 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	185 aa 21.1 kDa	No	0
UBXN11-014 ENSP00000363332 ENST00000374215	X6R8K8 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	247 aa 28 kDa	No	0
UBXN11-015 ENSP00000410357 ENST00000452980	X6RIY5 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	207 aa 23.6 kDa	No	0
UBXN11-016 ENSP00000394036 ENST00000423664	X6RDK7 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	148 aa 16.9 kDa	No	0
UBXN11-201 ENSP00000363334 ENST00000374217	Q5T124 [Direct mapping] UBX domain-containing protein 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] Show all	487 aa 54 kDa	No	0

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