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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ABHD3
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABHD3

Gene description

Abhydrolase domain containing 3

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (REH, RPMI-8226)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA010729
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PROGNOSTIC SUMMARY

Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA010729

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic staining was seen in almost all malignant tissues. Malignant gliomas were mainly negative or showed weak staining. Occasional nuclear staining was seen in many malignancies.

GENE INFORMATION

Gene name

ABHD3 (HGNC Symbol)

Synonyms

LABH3

Description

Abhydrolase domain containing 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

18

Cytoband

q11.2

Chromosome location (bp)

21650897 - 21704805

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158201 (version 83.38)

Entrez gene

171586

UniProt

Q8WU67 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WU67

Antibodypedia

ABHD3 antibodies

PROTEIN BROWSER

ABHD3-001
ABHD3-002
ABHD3-003
ABHD3-007
ABHD3-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABHD3-001
ENSP00000289119
ENST00000289119
Q8WU67 [Direct mapping]
Phospholipase ABHD3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004623 [phospholipase A2 activity]
GO:0005575 [cellular_component]
GO:0005886 [plasma membrane]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0016021 [integral component of membrane]
GO:0044281 [small molecule metabolic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0052739 [phosphatidylserine 1-acylhydrolase activity]
GO:0052740 [1-acyl-2-lysophosphatidylserine acylhydrolase activity]
Show all
409 aa
46 kDa
No 2
ABHD3-002
ENSP00000462578
ENST00000578270
J3KSP1 [Direct mapping]
Phospholipase ABHD3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
214 aa
24.4 kDa
No 0
ABHD3-003
ENSP00000462935
ENST00000580981
J3KTE1 [Direct mapping]
Phospholipase ABHD3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
356 aa
40.4 kDa
No 1
ABHD3-007
ENSP00000463848
ENST00000584464
J3QQR0 [Direct mapping]
Phospholipase ABHD3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
112 aa
12.6 kDa
No 0
ABHD3-009
ENSP00000463996
ENST00000580477
J3QR14 [Direct mapping]
Phospholipase ABHD3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
37 aa
3.8 kDa
No 0

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The Human Protein Atlas project is funded
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