Expression of ABHD3 in cancer - Summary - The Human Protein Atlas

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ABHD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD3
Gene description	Abhydrolase domain containing 3
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (REH, RPMI-8226)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010729
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PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable).
Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010729

GENE INFORMATION
Gene name	ABHD3 (HGNC Symbol)
Synonyms	LABH3
Description	Abhydrolase domain containing 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	21650897 - 21704805
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158201 (version 83.38)
Entrez gene	171586
UniProt	Q8WU67 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WU67
Antibodypedia	ABHD3 antibodies

PROTEIN BROWSER

ABHD3-001	ABHD3-002	ABHD3-003	ABHD3-007	ABHD3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD3-001 ENSP00000289119 ENST00000289119	Q8WU67 [Direct mapping] Phospholipase ABHD3 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004623 [phospholipase A2 activity] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0008970 [phosphatidylcholine 1-acylhydrolase activity] GO:0016021 [integral component of membrane] GO:0044281 [small molecule metabolic process] GO:0046470 [phosphatidylcholine metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0052739 [phosphatidylserine 1-acylhydrolase activity] GO:0052740 [1-acyl-2-lysophosphatidylserine acylhydrolase activity] Show all	409 aa 46 kDa	No	2
ABHD3-002 ENSP00000462578 ENST00000578270	J3KSP1 [Direct mapping] Phospholipase ABHD3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		214 aa 24.4 kDa	No	0
ABHD3-003 ENSP00000462935 ENST00000580981	J3KTE1 [Direct mapping] Phospholipase ABHD3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	356 aa 40.4 kDa	No	1
ABHD3-007 ENSP00000463848 ENST00000584464	J3QQR0 [Direct mapping] Phospholipase ABHD3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 12.6 kDa	No	0
ABHD3-009 ENSP00000463996 ENST00000580477	J3QR14 [Direct mapping] Phospholipase ABHD3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 3.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.