Expression of GPAT4 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GPAT4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPAT4
Gene description	Glycerol-3-phosphate acyltransferase 4
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA016471
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable), prostate cancer (favourable), urothelial cancer (favourable) and endometrial cancer (unfavourable).
Ovarian cancer p<0.001 Prostate cancer p<0.001 Urothelial cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016471

GENE INFORMATION
Gene name	GPAT4 (HGNC Symbol)
Synonyms	AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7
Description	Glycerol-3-phosphate acyltransferase 4 (HGNC Symbol)
Entrez gene summary	Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	41577187 - 41625001
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158669 (version 83.38)
Entrez gene	137964
UniProt	Q86UL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UL3
Antibodypedia	GPAT4 antibodies

PROTEIN BROWSER

GPAT4-001	GPAT4-003	GPAT4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPAT4-001 ENSP00000380184 ENST00000396987	Q86UL3 [Direct mapping] Glycerol-3-phosphate acyltransferase 4 Q2TU73 [Target identity:100%; Query identity:100%] 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta), isoform CRA_b; Testis spermatogenesis apoptosis-related protein 7 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002071 [glandular epithelial cell maturation] GO:0004366 [glycerol-3-phosphate O-acyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006631 [fatty acid metabolic process] GO:0006637 [acyl-CoA metabolic process] GO:0006641 [triglyceride metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0006656 [phosphatidylcholine biosynthetic process] GO:0007595 [lactation] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0030879 [mammary gland development] GO:0040014 [regulation of multicellular organism growth] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046339 [diacylglycerol metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	456 aa 52.1 kDa	No	4
GPAT4-003 ENSP00000428648 ENST00000520223	E5RGW3 [Direct mapping] Glycerol-3-phosphate acyltransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	29 aa 3.3 kDa	No	1
GPAT4-006 ENSP00000429477 ENST00000519853	E5RIA1 [Direct mapping] Glycerol-3-phosphate acyltransferase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	158 aa 18.2 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.