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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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GPAT4
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

GPAT4

Gene description

Glycerol-3-phosphate acyltransferase 4

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA016471
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PROGNOSTIC SUMMARY

Prognostic marker in ovarian cancer (unfavourable), prostate cancer (favourable), urothelial cancer (favourable) and endometrial cancer (unfavourable).
Ovarian cancer p<0.001
Prostate cancer p<0.001
Urothelial cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA016471

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong cytoplasmic staining. A few cases of renal and hepatocellular carcinomas were weakly stained or negative.

GENE INFORMATION

Gene name

GPAT4 (HGNC Symbol)

Synonyms

AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7

Description

Glycerol-3-phosphate acyltransferase 4 (HGNC Symbol)

Entrez gene summary

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

41577187 - 41625001

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158669 (version 83.38)

Entrez gene

137964

UniProt

Q86UL3 (UniProt - Evidence at protein level)

neXtProt

NX_Q86UL3

Antibodypedia

GPAT4 antibodies

PROTEIN BROWSER

GPAT4-001
GPAT4-003
GPAT4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GPAT4-001
ENSP00000380184
ENST00000396987
Q86UL3 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
Q2TU73 [Target identity:100%; Query identity:100%]
1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta), isoform CRA_b; Testis spermatogenesis apoptosis-related protein 7
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002071 [glandular epithelial cell maturation]
GO:0004366 [glycerol-3-phosphate O-acyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007595 [lactation]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016024 [CDP-diacylglycerol biosynthetic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0030879 [mammary gland development]
GO:0040014 [regulation of multicellular organism growth]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046339 [diacylglycerol metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
456 aa
52.1 kDa
No 4
GPAT4-003
ENSP00000428648
ENST00000520223
E5RGW3 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
29 aa
3.3 kDa
No 1
GPAT4-006
ENSP00000429477
ENST00000519853
E5RIA1 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
158 aa
18.2 kDa
No 2

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