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GPAT4

GENERAL INFORMATION

Gene name

 GPAT4

Gene description

 Glycerol-3-phosphate acyltransferase 4

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016471
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GPAT4 (HGNC Symbol)

Synonyms

 AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7

Description

 Glycerol-3-phosphate acyltransferase 4 (HGNC Symbol)

Entrez gene summary

 Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 41577187 - 41625001

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158669 (version 83.38)

Entrez gene

 137964

UniProt

 Q86UL3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86UL3

Antibodypedia

 GPAT4 antibodies

PROTEIN BROWSER
GPAT4-001
GPAT4-003
GPAT4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GPAT4-001
ENSP00000380184
ENST00000396987
Q86UL3 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
Q2TU73 [Target identity:100%; Query identity:100%]
1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta), isoform CRA_b; Testis spermatogenesis apoptosis-related protein 7
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002071 [glandular epithelial cell maturation]
GO:0004366 [glycerol-3-phosphate O-acyltransferase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006631 [fatty acid metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007595 [lactation]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016024 [CDP-diacylglycerol biosynthetic process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0019432 [triglyceride biosynthetic process]
GO:0030879 [mammary gland development]
GO:0040014 [regulation of multicellular organism growth]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046339 [diacylglycerol metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
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 456 aa
52.1 kDa 		No 4
GPAT4-003
ENSP00000428648
ENST00000520223
E5RGW3 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
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 29 aa
3.3 kDa 		No 1
GPAT4-006
ENSP00000429477
ENST00000519853
E5RIA1 [Direct mapping]
Glycerol-3-phosphate acyltransferase 4
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 158 aa
18.2 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.