Expression of ITLN2 in cancer - Summary - The Human Protein Atlas

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ITLN2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ITLN2
Gene description	Intelectin 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Group enriched (HEL, HMC-1, SK-MEL-30)
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Extracellular positivity in goblet cells, mainly in small intestine and duodenum.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA006683
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006683

GENE INFORMATION
Gene name	ITLN2 (HGNC Symbol)
Synonyms	HL-2
Description	Intelectin 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	160945025 - 160954799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158764 (version 83.38)
Entrez gene	142683
UniProt	Q8WWU7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WWU7
Antibodypedia	ITLN2 antibodies

PROTEIN BROWSER

ITLN2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITLN2-001 ENSP00000357008 ENST00000368029	Q8WWU7 [Direct mapping] Intelectin-2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0030246 [carbohydrate binding] Show all	325 aa 36.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.