Cell atlas - NDUFS2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NDUFS2
Gene description	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (validated)
Additional location	In addition localized to the Nucleoplasm (validated)
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA055140
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (validated)

Additional location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA055140	A-431	Nucleoplasm
HPA055140	A-431	Mitochondria
HPA055140	HeLa	Mitochondria
HPA055140	U-2 OS	Mitochondria

MOUSE CELLS

Main location

Mitochondria

Additional location

Nucleoplasm

Mouse gene

ENSMUSG00000013593 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055140	NIH 3T3	Nucleoplasm
	HPA055140	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	NDUFS2 (HGNC Symbol)
Synonyms	CI-49
Description	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161197104 - 161214395
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158864 (version 83.38)
Entrez gene	4720
UniProt	O75306 (UniProt - Evidence at protein level)
neXtProt	NX_O75306
Antibodypedia	NDUFS2 antibodies

PROTEIN BROWSER

NDUFS2-001	NDUFS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFS2-001 ENSP00000356972 ENST00000367993	O75306 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003954 [NADH dehydrogenase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005759 [mitochondrial matrix] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006979 [response to oxidative stress] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0022904 [respiratory electron transport chain] GO:0031625 [ubiquitin protein ligase binding] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048038 [quinone binding] GO:0051287 [NAD binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	463 aa 52.5 kDa	No	0
NDUFS2-201 ENSP00000376018 ENST00000392179	O75306 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003954 [NADH dehydrogenase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005759 [mitochondrial matrix] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006979 [response to oxidative stress] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009055 [electron carrier activity] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0022904 [respiratory electron transport chain] GO:0031625 [ubiquitin protein ligase binding] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0048038 [quinone binding] GO:0051287 [NAD binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	457 aa 51.9 kDa	No	0