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NDUFS2

GENERAL INFORMATION

Gene name

 NDUFS2

Gene description

 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA055140 , HPA061953
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055140
HPA061953

GENE INFORMATION

Gene name

 NDUFS2 (HGNC Symbol)

Synonyms

 CI-49

Description

 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 q23.3

Chromosome location (bp)

 161197104 - 161214395

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158864 (version 83.38)

Entrez gene

 4720

UniProt

 O75306 (UniProt - Evidence at protein level)

neXtProt

 NX_O75306

Antibodypedia

 NDUFS2 antibodies

PROTEIN BROWSER
NDUFS2-001
NDUFS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDUFS2-001
ENSP00000356972
ENST00000367993
O75306 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0006979 [response to oxidative stress]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0016651 [oxidoreductase activity, acting on NAD(P)H]
GO:0022904 [respiratory electron transport chain]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051287 [NAD binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
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 463 aa
52.5 kDa 		No 0
NDUFS2-201
ENSP00000376018
ENST00000392179
O75306 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0006979 [response to oxidative stress]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0009055 [electron carrier activity]
GO:0016651 [oxidoreductase activity, acting on NAD(P)H]
GO:0022904 [respiratory electron transport chain]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051287 [NAD binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 457 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.