Cell atlas - SLC5A11 - The Human Protein Atlas

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SLC5A11

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SLC5A11
Gene description	Solute carrier family 5 (sodium/inositol cotransporter), member 11
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (Hep G2, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035331
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035331	Hep G2	Nucleoplasm
	HPA035331	U-2 OS	Nucleus
	HPA035331	U-2 OS	Cytosol
	HPA035331	U-251 MG	Nucleoplasm
	HPA035331	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SLC5A11 (HGNC Symbol)
Synonyms	KST1, SGLT6, SMIT2
Description	Solute carrier family 5 (sodium/inositol cotransporter), member 11 (HGNC Symbol)
Entrez gene summary	Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	p12.1
Chromosome location (bp)	24845841 - 24911628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158865 (version 83.38)
Entrez gene	115584
UniProt	Q8WWX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWX8
Antibodypedia	SLC5A11 antibodies

PROTEIN BROWSER

SLC5A11-001	SLC5A11-003	SLC5A11-004	SLC5A11-005	SLC5A11-006	SLC5A11-009	SLC5A11-201	SLC5A11-202	SLC5A11-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A11-001 ENSP00000289932 ENST00000347898	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	675 aa 74 kDa	No	>9
SLC5A11-003 ENSP00000456234 ENST00000568579	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	605 aa 66.6 kDa	No	>9
SLC5A11-004 ENSP00000454401 ENST00000567758	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	640 aa 69.9 kDa	No	>9
SLC5A11-005 ENSP00000457179 ENST00000565769	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	611 aa 67.2 kDa	No	>9
SLC5A11-006 ENSP00000456376 ENST00000569071	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	519 aa 57.1 kDa	Yes	9
SLC5A11-009 ENSP00000454732 ENST00000569520	H3BN85 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	91 aa 9.6 kDa	No	1
SLC5A11-201 ENSP00000416782 ENST00000424767	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	640 aa 69.9 kDa	No	>9
SLC5A11-202 ENSP00000389606 ENST00000449109	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	519 aa 57.1 kDa	Yes	9
SLC5A11-203 ENSP00000441384 ENST00000545376	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	605 aa 66.6 kDa	No	>9

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.