Expression of SLC5A11 in cancer - Summary - The Human Protein Atlas

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SLC5A11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC5A11
Gene description	Solute carrier family 5 (sodium/inositol cotransporter), member 11
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Hep G2, Karpas-707)
HPA (normal tissue):	Group enriched (cerebral cortex, duodenum, kidney, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035331
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035331

GENE INFORMATION
Gene name	SLC5A11 (HGNC Symbol)
Synonyms	KST1, SGLT6, SMIT2
Description	Solute carrier family 5 (sodium/inositol cotransporter), member 11 (HGNC Symbol)
Entrez gene summary	Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
Chromosome	16
Cytoband	p12.1
Chromosome location (bp)	24845841 - 24911628
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000158865 (version 83.38)
Entrez gene	115584
UniProt	Q8WWX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WWX8
Antibodypedia	SLC5A11 antibodies

PROTEIN BROWSER

SLC5A11-001	SLC5A11-003	SLC5A11-004	SLC5A11-005	SLC5A11-006	SLC5A11-009	SLC5A11-201	SLC5A11-202	SLC5A11-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A11-001 ENSP00000289932 ENST00000347898	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	675 aa 74 kDa	No	>9
SLC5A11-003 ENSP00000456234 ENST00000568579	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	605 aa 66.6 kDa	No	>9
SLC5A11-004 ENSP00000454401 ENST00000567758	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	640 aa 69.9 kDa	No	>9
SLC5A11-005 ENSP00000457179 ENST00000565769	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	611 aa 67.2 kDa	No	>9
SLC5A11-006 ENSP00000456376 ENST00000569071	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	519 aa 57.1 kDa	Yes	9
SLC5A11-009 ENSP00000454732 ENST00000569520	H3BN85 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	91 aa 9.6 kDa	No	1
SLC5A11-201 ENSP00000416782 ENST00000424767	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	640 aa 69.9 kDa	No	>9
SLC5A11-202 ENSP00000389606 ENST00000449109	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	519 aa 57.1 kDa	Yes	9
SLC5A11-203 ENSP00000441384 ENST00000545376	Q8WWX8 [Direct mapping] Sodium/myo-inositol cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006915 [apoptotic process] GO:0008643 [carbohydrate transport] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	605 aa 66.6 kDa	No	>9

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The Human Protein Atlas

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