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CDC42SE2

GENERAL INFORMATION

Gene name

 CDC42SE2

Gene description

 CDC42 small effector 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, most abundant in a subset of lymhocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA038624
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and urothelial cancer (favourable).
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038624

GENE INFORMATION

Gene name

 CDC42SE2 (HGNC Symbol)

Synonyms

 FLJ21967, SPEC2

Description

 CDC42 small effector 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 131245493 - 131398447

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000158985 (version 83.38)

Entrez gene

 56990

UniProt

 Q9NRR3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRR3

Antibodypedia

 CDC42SE2 antibodies

PROTEIN BROWSER
CDC42SE2-001
CDC42SE2-002
CDC42SE2-005
CDC42SE2-011
CDC42SE2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42SE2-001
ENSP00000426779
ENST00000503291
D6REL0 [Direct mapping]
CDC42 small effector protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 57 aa
5.9 kDa 		No 0
CDC42SE2-002
ENSP00000353706
ENST00000360515
Q9NRR3 [Direct mapping]
CDC42 small effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008360 [regulation of cell shape]
GO:0009966 [regulation of signal transduction]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
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 84 aa
9.2 kDa 		No 0
CDC42SE2-005
ENSP00000427421
ENST00000505065
Q9NRR3 [Direct mapping]
CDC42 small effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008360 [regulation of cell shape]
GO:0009966 [regulation of signal transduction]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
Show all
 84 aa
9.2 kDa 		No 0
CDC42SE2-011
ENSP00000425292
ENST00000502582
H0Y9W5 [Direct mapping]
CDC42 small effector protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0007165 [signal transduction]
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 54 aa
6.1 kDa 		No 0
CDC42SE2-201
ENSP00000378667
ENST00000395246
Q9NRR3 [Direct mapping]
CDC42 small effector protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006909 [phagocytosis]
GO:0007165 [signal transduction]
GO:0008360 [regulation of cell shape]
GO:0009966 [regulation of signal transduction]
GO:0042995 [cell projection]
GO:0070062 [extracellular exosome]
Show all
 84 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.