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GART

GENERAL INFORMATION

Gene name

 GART

Gene description

 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 2 antibodies.
HPA002119 , HPA005779
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), head and neck cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA002119
HPA005779

GENE INFORMATION

Gene name

 GART (HGNC Symbol)

Synonyms

 PGFT, PRGS

Description

 Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33503931 - 33543491

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159131 (version 83.38)

Entrez gene

 2618

UniProt

 P22102 (UniProt - Evidence at protein level)

neXtProt

 NX_P22102

Antibodypedia

 GART antibodies

PROTEIN BROWSER
GART-001
GART-003
GART-004
GART-006
GART-007
GART-008
GART-009
GART-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GART-001
ENSP00000371253
ENST00000381831
P22102 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity]
GO:0004644 [phosphoribosylglycinamide formyltransferase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0006544 [glycine metabolic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009156 [ribonucleoside monophosphate biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0010033 [response to organic substance]
GO:0010035 [response to inorganic substance]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0021549 [cerebellum development]
GO:0021987 [cerebral cortex development]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046654 [tetrahydrofolate biosynthetic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 1010 aa
107.8 kDa 		No 0
GART-003
ENSP00000371236
ENST00000381815
P22102 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity]
GO:0004644 [phosphoribosylglycinamide formyltransferase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 1010 aa
107.8 kDa 		No 0
GART-004
ENSP00000354388
ENST00000361093
P22102 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Ligase
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity]
GO:0004644 [phosphoribosylglycinamide formyltransferase activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0008168 [methyltransferase activity]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 433 aa
46 kDa 		No 0
GART-006
ENSP00000371261
ENST00000381839
P22102 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Ligase
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity]
GO:0004644 [phosphoribosylglycinamide formyltransferase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0008168 [methyltransferase activity]
GO:0009058 [biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016742 [hydroxymethyl-, formyl- and related transferase activity]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 1010 aa
107.8 kDa 		No 0
GART-007
ENSP00000413040
ENST00000430874
C9JTV6 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0005524 [ATP binding]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0046872 [metal ion binding]
Show all
 241 aa
25.2 kDa 		No 0
GART-008
ENSP00000413803
ENST00000438059
C9JKQ7 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0009113 [purine nucleobase biosynthetic process]
Show all
 138 aa
14.7 kDa 		No 0
GART-009
ENSP00000398631
ENST00000426819
C9JBJ1 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0005524 [ATP binding]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0046872 [metal ion binding]
Show all
 232 aa
24.3 kDa 		No 0
GART-010
ENSP00000407783
ENST00000441403
C9JZG2 [Direct mapping]
Trifunctional purine biosynthetic protein adenosine-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004637 [phosphoribosylamine-glycine ligase activity]
GO:0009113 [purine nucleobase biosynthetic process]
Show all
 136 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.