Tissue expression of GART - Summary - The Human Protein Atlas

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GART

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GART
Gene description	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 2 antibodies. HPA002119 , HPA005779
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GART (HGNC Symbol)
Synonyms	PGFT, PRGS
Description	Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33503931 - 33543491
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159131 (version 83.38)
Entrez gene	2618
UniProt	P22102 (UniProt - Evidence at protein level)
neXtProt	NX_P22102
Antibodypedia	GART antibodies

PROTEIN BROWSER

GART-001	GART-003	GART-004	GART-006	GART-007	GART-008	GART-009	GART-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GART-001 ENSP00000371253 ENST00000381831	P22102 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase Show all	Enzymes ENZYME proteins Transferases Ligase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003360 [brainstem development] GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity] GO:0004644 [phosphoribosylglycinamide formyltransferase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0006544 [glycine metabolic process] GO:0008168 [methyltransferase activity] GO:0009058 [biosynthetic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0009156 [ribonucleoside monophosphate biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0010033 [response to organic substance] GO:0010035 [response to inorganic substance] GO:0016742 [hydroxymethyl-, formyl- and related transferase activity] GO:0021549 [cerebellum development] GO:0021987 [cerebral cortex development] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] GO:0046654 [tetrahydrofolate biosynthetic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1010 aa 107.8 kDa	No	0
GART-003 ENSP00000371236 ENST00000381815	P22102 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase Show all	Enzymes ENZYME proteins Transferases Ligase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity] GO:0004644 [phosphoribosylglycinamide formyltransferase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0008168 [methyltransferase activity] GO:0009058 [biosynthetic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0016742 [hydroxymethyl-, formyl- and related transferase activity] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1010 aa 107.8 kDa	No	0
GART-004 ENSP00000354388 ENST00000361093	P22102 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase Show all	Enzymes ENZYME proteins Transferases Ligase Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity] GO:0004644 [phosphoribosylglycinamide formyltransferase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0008168 [methyltransferase activity] GO:0009113 [purine nucleobase biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	433 aa 46 kDa	No	0
GART-006 ENSP00000371261 ENST00000381839	P22102 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylamine--glycine ligase Phosphoribosylformylglycinamidine cyclo-ligase Phosphoribosylglycinamide formyltransferase Show all	Enzymes ENZYME proteins Transferases Ligase SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0004641 [phosphoribosylformylglycinamidine cyclo-ligase activity] GO:0004644 [phosphoribosylglycinamide formyltransferase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006144 [purine nucleobase metabolic process] GO:0006189 ['de novo' IMP biosynthetic process] GO:0008168 [methyltransferase activity] GO:0009058 [biosynthetic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0009168 [purine ribonucleoside monophosphate biosynthetic process] GO:0016742 [hydroxymethyl-, formyl- and related transferase activity] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1010 aa 107.8 kDa	No	0
GART-007 ENSP00000413040 ENST00000430874	C9JTV6 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0005524 [ATP binding] GO:0009113 [purine nucleobase biosynthetic process] GO:0046872 [metal ion binding] Show all	241 aa 25.2 kDa	No	0
GART-008 ENSP00000413803 ENST00000438059	C9JKQ7 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0009113 [purine nucleobase biosynthetic process] Show all	138 aa 14.7 kDa	No	0
GART-009 ENSP00000398631 ENST00000426819	C9JBJ1 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0005524 [ATP binding] GO:0009113 [purine nucleobase biosynthetic process] GO:0046872 [metal ion binding] Show all	232 aa 24.3 kDa	No	0
GART-010 ENSP00000407783 ENST00000441403	C9JZG2 [Direct mapping] Trifunctional purine biosynthetic protein adenosine-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004637 [phosphoribosylamine-glycine ligase activity] GO:0009113 [purine nucleobase biosynthetic process] Show all	136 aa 14.5 kDa	No	0

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