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SON

GENERAL INFORMATION

Gene name

 SON

Gene description

 SON DNA binding protein

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA023535
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023535

GENE INFORMATION

Gene name

 SON (HGNC Symbol)

Synonyms

 BASS1, C21orf50, DBP-5, FLJ21099, FLJ33914, KIAA1019, NREBP

Description

 SON DNA binding protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33542618 - 33577481

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159140 (version 83.38)

Entrez gene

 6651

UniProt

 P18583 (UniProt - Evidence at protein level)

neXtProt

 NX_P18583

Antibodypedia

 SON antibodies

PROTEIN BROWSER
SON-001
SON-002
SON-003
SON-006
SON-007
SON-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SON-001
ENSP00000348984
ENST00000356577
P18583 [Direct mapping]
Protein SON
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0043484 [regulation of RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0050733 [RS domain binding]
GO:0051726 [regulation of cell cycle]
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 2426 aa
263.8 kDa 		No 0
SON-002
ENSP00000371111
ENST00000381692
J3QSZ5 [Direct mapping]
Protein SON
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
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 454 aa
50.3 kDa 		No 0
SON-003
ENSP00000300278
ENST00000300278
P18583 [Direct mapping]
Protein SON
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0043484 [regulation of RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0051726 [regulation of cell cycle]
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 2303 aa
250.4 kDa 		No 0
SON-006
ENSP00000371095
ENST00000381679
P18583 [Direct mapping]
Protein SON
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0000910 [cytokinesis]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0043484 [regulation of RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0051726 [regulation of cell cycle]
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 2108 aa
228.2 kDa 		No 0
SON-007
ENSP00000400985
ENST00000436227
H7C1M2 [Direct mapping]
Protein SON
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
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 1454 aa
159.9 kDa 		No 0
SON-008
ENSP00000405807
ENST00000421541
H7C2G8 [Direct mapping]
Protein SON
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 343 aa
39.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.