Expression of ADPGK in cancer - Summary - The Human Protein Atlas

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ADPGK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADPGK
Gene description	ADP-dependent glucokinase
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA045194
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and prostate cancer (unfavourable).
Renal cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045194

GENE INFORMATION
Gene name	ADPGK (HGNC Symbol)
Synonyms	ADP-GK, DKFZp434B195
Description	ADP-dependent glucokinase (HGNC Symbol)
Entrez gene summary	ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q24.1
Chromosome location (bp)	72751369 - 72785846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159322 (version 83.38)
Entrez gene	83440
UniProt	Q9BRR6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRR6
Antibodypedia	ADPGK antibodies

PROTEIN BROWSER

ADPGK-002	ADPGK-006	ADPGK-011	ADPGK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADPGK-002 ENSP00000312250 ENST00000311669	Q9BRR6 [Direct mapping] ADP-dependent glucokinase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006096 [glycolytic process] GO:0016020 [membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0043843 [ADP-specific glucokinase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	496 aa 54 kDa	Yes	0
ADPGK-006 ENSP00000457447 ENST00000565814	H3BU35 [Direct mapping] ADP-dependent glucokinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005975 [carbohydrate metabolic process] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] Show all	154 aa 17 kDa	No	0
ADPGK-011 ENSP00000456387 ENST00000563907	H3BRS6 [Direct mapping] ADP-dependent glucokinase Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005975 [carbohydrate metabolic process] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] Show all	204 aa 21.8 kDa	No	0
ADPGK-201 ENSP00000397694 ENST00000456471	Q9BRR6 [Direct mapping] ADP-dependent glucokinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006096 [glycolytic process] GO:0016020 [membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0043843 [ADP-specific glucokinase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] Show all	222 aa 24.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.