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PGLYRP3

GENERAL INFORMATION

Gene name

 PGLYRP3

Gene description

 Peptidoglycan recognition protein 3

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Group enriched (HaCaT, HDLM-2, hTCEpi)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. RNA data suggests expression in squamous epithelia.

Reliability score

 Uncertain based on 1 antibody.
HPA030369
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030369

GENE INFORMATION

Gene name

 PGLYRP3 (HGNC Symbol)

Synonyms

 PGLYRPIalpha, PGRP-Ialpha, PGRPIA

Description

 Peptidoglycan recognition protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153297862 - 153310718

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159527 (version 83.38)

Entrez gene

 114771

UniProt

 Q96LB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96LB9

Antibodypedia

 PGLYRP3 antibodies

PROTEIN BROWSER
PGLYRP3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PGLYRP3-001
ENSP00000290722
ENST00000290722
Q96LB9 [Direct mapping]
Peptidoglycan recognition protein 3
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0002221 [pattern recognition receptor signaling pathway]
GO:0005576 [extracellular region]
GO:0005622 [intracellular]
GO:0008270 [zinc ion binding]
GO:0008745 [N-acetylmuramoyl-L-alanine amidase activity]
GO:0009253 [peptidoglycan catabolic process]
GO:0016019 [peptidoglycan receptor activity]
GO:0016020 [membrane]
GO:0016045 [detection of bacterium]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032827 [negative regulation of natural killer cell differentiation involved in immune response]
GO:0042834 [peptidoglycan binding]
GO:0044117 [growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0050830 [defense response to Gram-positive bacterium]
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 341 aa
37.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.