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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADGRG5
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADGRG5

Gene description

Adhesion G protein-coupled receptor G5

Protein class

G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA007133
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA007133

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic positivity was observed in cancer cells in several gliomas and renal cancers. Immune cells were strongly stained in essentially all cancer tissues. Most remaining cancer cells were negative.

GENE INFORMATION

Gene name

ADGRG5 (HGNC Symbol)

Synonyms

GPR114, PGR27

Description

Adhesion G protein-coupled receptor G5 (HGNC Symbol)

Entrez gene summary

Chromosome

16

Cytoband

q21

Chromosome location (bp)

57542421 - 57591681

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159618 (version 83.38)

Entrez gene

221188

UniProt

Q8IZF4 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8IZF4

Antibodypedia

ADGRG5 antibodies

PROTEIN BROWSER

ADGRG5-001
ADGRG5-006
ADGRG5-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADGRG5-001
ENSP00000342981
ENST00000340339
Q8IZF4 [Direct mapping]
Adhesion G-protein coupled receptor G5
A0A024R6S3 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 114, isoform CRA_a
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
528 aa
59 kDa
Yes 7
ADGRG5-006
ENSP00000290823
ENST00000349457
Q8IZF4 [Direct mapping]
Adhesion G-protein coupled receptor G5
A0A024R6S3 [Target identity:100%; Query identity:100%]
G protein-coupled receptor 114, isoform CRA_a
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
528 aa
59 kDa
Yes 7
ADGRG5-009
ENSP00000482481
ENST00000615867
A0A087WZA0 [Direct mapping]
Adhesion G-protein-coupled receptor G5
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
221 aa
24.8 kDa
Yes 0

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