Expression of ADGRG5 in cancer - Summary - The Human Protein Atlas

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ADGRG5

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADGRG5
Gene description	Adhesion G protein-coupled receptor G5
Protein class	G-protein coupled receptors Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA007133
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007133

GENE INFORMATION
Gene name	ADGRG5 (HGNC Symbol)
Synonyms	GPR114, PGR27
Description	Adhesion G protein-coupled receptor G5 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q21
Chromosome location (bp)	57542421 - 57591681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159618 (version 83.38)
Entrez gene	221188
UniProt	Q8IZF4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IZF4
Antibodypedia	ADGRG5 antibodies

PROTEIN BROWSER

ADGRG5-001	ADGRG5-006	ADGRG5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRG5-001 ENSP00000342981 ENST00000340339	Q8IZF4 [Direct mapping] Adhesion G-protein coupled receptor G5 A0A024R6S3 [Target identity:100%; Query identity:100%] G protein-coupled receptor 114, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	528 aa 59 kDa	Yes	7
ADGRG5-006 ENSP00000290823 ENST00000349457	Q8IZF4 [Direct mapping] Adhesion G-protein coupled receptor G5 A0A024R6S3 [Target identity:100%; Query identity:100%] G protein-coupled receptor 114, isoform CRA_a Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	528 aa 59 kDa	Yes	7
ADGRG5-009 ENSP00000482481 ENST00000615867	A0A087WZA0 [Direct mapping] Adhesion G-protein-coupled receptor G5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		221 aa 24.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.