Cell atlas - ZYX - The Human Protein Atlas

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ZYX

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	ZYX
Gene description	Zyxin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the focal adhesion sites.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Focal adhesion sites (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA004835
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the focal adhesion sites.

Main location

Focal adhesion sites (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA004835	A-431	Focal adhesion sites
	HPA004835	U-2 OS	Focal adhesion sites
	HPA004835	U-251 MG	Focal adhesion sites
	HPA004835	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ZYX
Synonyms
Description	Zyxin (HGNC Symbol)
Entrez gene summary	Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	143381080 - 143391111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159840 (version 83.38)
Entrez gene	7791
UniProt	Q15942 (UniProt - Evidence at protein level)
neXtProt	NX_Q15942
Antibodypedia	ZYX antibodies

PROTEIN BROWSER

ZYX-001	ZYX-003	ZYX-005	ZYX-006	ZYX-007	ZYX-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZYX-001 ENSP00000324422 ENST00000322764	Q15942 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0016032 [viral process] GO:0043149 [stress fiber assembly] GO:0044822 [poly(A) RNA binding] GO:0050727 [regulation of inflammatory response] Show all	572 aa 61.3 kDa	No	0
ZYX-003 ENSP00000403714 ENST00000446634	C9JJK5 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	171 aa 19.1 kDa	No	0
ZYX-005 ENSP00000413467 ENST00000449630	H7C3R3 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 18.6 kDa	No	0
ZYX-006 ENSP00000346417 ENST00000354434	H0Y2Y8 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] Show all	540 aa 57.6 kDa	No	0
ZYX-007 ENSP00000376642 ENST00000392910	Q15942 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0016032 [viral process] GO:0043149 [stress fiber assembly] GO:0044822 [poly(A) RNA binding] Show all	415 aa 45.1 kDa	No	0
ZYX-010 ENSP00000400537 ENST00000457235	C9IZ41 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.