Expression of ZYX in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ZYX
Gene description	Zyxin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in subsets of immune cells as well as smooth muscle, lung macrophages, myoepithelial cells, bone marrow and platelets.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 4 antibodies. HPA004835 , HPA073497 , CAB009321 , CAB075747
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004835	HPA073497	CAB009321	CAB075747

GENE INFORMATION
Gene name	ZYX
Synonyms
Description	Zyxin (HGNC Symbol)
Entrez gene summary	Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	143381080 - 143391111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159840 (version 83.38)
Entrez gene	7791
UniProt	Q15942 (UniProt - Evidence at protein level)
neXtProt	NX_Q15942
Antibodypedia	ZYX antibodies

PROTEIN BROWSER

ZYX-001	ZYX-003	ZYX-005	ZYX-006	ZYX-007	ZYX-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZYX-001 ENSP00000324422 ENST00000322764	Q15942 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0016032 [viral process] GO:0043149 [stress fiber assembly] GO:0044822 [poly(A) RNA binding] GO:0050727 [regulation of inflammatory response] Show all	572 aa 61.3 kDa	No	0
ZYX-003 ENSP00000403714 ENST00000446634	C9JJK5 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	171 aa 19.1 kDa	No	0
ZYX-005 ENSP00000413467 ENST00000449630	H7C3R3 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 18.6 kDa	No	0
ZYX-006 ENSP00000346417 ENST00000354434	H0Y2Y8 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0008270 [zinc ion binding] Show all	540 aa 57.6 kDa	No	0
ZYX-007 ENSP00000376642 ENST00000392910	Q15942 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007267 [cell-cell signaling] GO:0008270 [zinc ion binding] GO:0016032 [viral process] GO:0043149 [stress fiber assembly] GO:0044822 [poly(A) RNA binding] Show all	415 aa 45.1 kDa	No	0
ZYX-010 ENSP00000400537 ENST00000457235	C9IZ41 [Direct mapping] Zyxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 17.1 kDa	No	0