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NPR2

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GENERAL INFORMATION

Gene name

 NPR2

Gene description

 Natriuretic peptide receptor 2

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (ASC TERT1, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NPR2 (HGNC Symbol)

Synonyms

 AMDM, ANPb, ANPRB, GUCY2B, NPRB

Description

 Natriuretic peptide receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 35792154 - 35809732

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000159899 (version 83.38)

Entrez gene

 4882

UniProt

 P20594 (UniProt - Evidence at protein level)

neXtProt

 NX_P20594

Antibodypedia

 NPR2 antibodies

PROTEIN BROWSER
NPR2-001
NPR2-003
NPR2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPR2-001
ENSP00000341083
ENST00000342694
P20594 [Direct mapping]
Atrial natriuretic peptide receptor 2
Show all
Enzymes
   ENZYME proteins
   Lyases
   Kinases
   RGC receptor guanylate cyclase kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0004383 [guanylate cyclase activity]
GO:0004672 [protein kinase activity]
GO:0004872 [receptor activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005886 [plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0008217 [regulation of blood pressure]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0016941 [natriuretic peptide receptor activity]
GO:0017046 [peptide hormone binding]
GO:0035556 [intracellular signal transduction]
GO:0042562 [hormone binding]
GO:0042802 [identical protein binding]
GO:0044702 [single organism reproductive process]
GO:0051447 [negative regulation of meiotic cell cycle]
GO:0060348 [bone development]
GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus]
GO:1900194 [negative regulation of oocyte maturation]
Show all
 1047 aa
117 kDa 		Yes 1
NPR2-003
ENSP00000399204
ENST00000421267
H7C1A1 [Direct mapping]
Atrial natriuretic peptide receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 275 aa
30.9 kDa 		No 0
NPR2-005
ENSP00000393029
ENST00000447210
H7C056 [Direct mapping]
Atrial natriuretic peptide receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0005622 [intracellular]
GO:0006182 [cGMP biosynthetic process]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0035556 [intracellular signal transduction]
Show all
 164 aa
19 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.