Tissue expression of NPR2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NPR2
Gene description	Natriuretic peptide receptor 2
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (cerebellum, cervix, uterine)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, cervix, uterine)

GENE INFORMATION
Gene name	NPR2 (HGNC Symbol)
Synonyms	AMDM, ANPb, ANPRB, GUCY2B, NPRB
Description	Natriuretic peptide receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	35792154 - 35809732
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000159899 (version 83.38)
Entrez gene	4882
UniProt	P20594 (UniProt - Evidence at protein level)
neXtProt	NX_P20594
Antibodypedia	NPR2 antibodies

PROTEIN BROWSER

NPR2-001	NPR2-003	NPR2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPR2-001 ENSP00000341083 ENST00000342694	P20594 [Direct mapping] Atrial natriuretic peptide receptor 2 Show all	Enzymes ENZYME proteins Lyases Kinases RGC receptor guanylate cyclase kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0004383 [guanylate cyclase activity] GO:0004672 [protein kinase activity] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005886 [plasma membrane] GO:0006182 [cGMP biosynthetic process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007168 [receptor guanylyl cyclase signaling pathway] GO:0008074 [guanylate cyclase complex, soluble] GO:0008217 [regulation of blood pressure] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0016941 [natriuretic peptide receptor activity] GO:0017046 [peptide hormone binding] GO:0035556 [intracellular signal transduction] GO:0042562 [hormone binding] GO:0042802 [identical protein binding] GO:0044702 [single organism reproductive process] GO:0051447 [negative regulation of meiotic cell cycle] GO:0060348 [bone development] GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:1900194 [negative regulation of oocyte maturation] Show all	1047 aa 117 kDa	Yes	1
NPR2-003 ENSP00000399204 ENST00000421267	H7C1A1 [Direct mapping] Atrial natriuretic peptide receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004383 [guanylate cyclase activity] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006182 [cGMP biosynthetic process] GO:0006468 [protein phosphorylation] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0035556 [intracellular signal transduction] Show all	275 aa 30.9 kDa	No	0
NPR2-005 ENSP00000393029 ENST00000447210	H7C056 [Direct mapping] Atrial natriuretic peptide receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004383 [guanylate cyclase activity] GO:0005622 [intracellular] GO:0006182 [cGMP biosynthetic process] GO:0009190 [cyclic nucleotide biosynthetic process] GO:0016021 [integral component of membrane] GO:0016849 [phosphorus-oxygen lyase activity] GO:0035556 [intracellular signal transduction] Show all	164 aa 19 kDa	No	0