Expression of ATAD3B in cancer - Summary - The Human Protein Atlas

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ATAD3B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATAD3B
Gene description	ATPase family, AAA domain containing 3B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA058968
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058968

GENE INFORMATION
Gene name	ATAD3B (HGNC Symbol)
Synonyms	KIAA1273, TOB3
Description	ATPase family, AAA domain containing 3B (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is localized to the mitochondrial inner membrane, where it can bind to a highly-related protein, ATAD3A. ATAD3A appears to interact with matrix nucleoid complexes, and the encoded protein negatively regulates that interaction. This gene is expressed almost exclusively in pluripotent embryonic stem cells and some cancer cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1471769 - 1497848
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000160072 (version 83.38)
Entrez gene	83858
UniProt	Q5T9A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T9A4
Antibodypedia	ATAD3B antibodies

PROTEIN BROWSER

ATAD3B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATAD3B-001 ENSP00000311766 ENST00000308647	Q5T9A4 [Direct mapping] ATPase family AAA domain-containing protein 3B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005743 [mitochondrial inner membrane] Show all	648 aa 72.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.