We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ABCG1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ABCG1

Gene description

ATP-binding cassette, sub-family G (WHITE), member 1

Protein class

Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MCF7, MOLT-4, SCLC-21H)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, including macrophages.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA031470 , HPA031471
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA031470
HPA031471

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells were negative. A few cases of skin, pancreatic and gastric cancers exhibited moderate cytoplasmic and/or nuclear immunoreactivity.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Thyroid cancers and several cases of ovarian, endometrial and liver cancers exhibited weak to moderate cytoplasmic staining. The remaining tumors were negative.

GENE INFORMATION

Gene name

ABCG1 (HGNC Symbol)

Synonyms

ABC8

Description

ATP-binding cassette, sub-family G (WHITE), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

42199689 - 42297244

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160179 (version 83.38)

Entrez gene

9619

UniProt

P45844 (UniProt - Evidence at protein level)

neXtProt

NX_P45844

Antibodypedia

ABCG1 antibodies

PROTEIN BROWSER

ABCG1-001
ABCG1-002
ABCG1-004
ABCG1-005
ABCG1-006
ABCG1-008
ABCG1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG1-001
ENSP00000381467
ENST00000398449
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
666 aa
74.2 kDa
Yes 7
ABCG1-002
ENSP00000381475
ENST00000398457
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
668 aa
74.6 kDa
No 7
ABCG1-004
ENSP00000291524
ENST00000347800
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
663 aa
74 kDa
No 7
ABCG1-005
ENSP00000339744
ENST00000343687
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
677 aa
75.4 kDa
No 7
ABCG1-006
ENSP00000354995
ENST00000361802
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010888 [negative regulation of lipid storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0030301 [cholesterol transport]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055099 [response to high density lipoprotein particle]
GO:1901998 [toxin transport]
Show all
678 aa
75.6 kDa
Yes 7
ABCG1-008
ENSP00000381464
ENST00000398437
E9PGV9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
Show all
824 aa
90.9 kDa
No 7
ABCG1-010
ENSP00000414541
ENST00000450121
C9JKD9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
257 aa
27.8 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.