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ABCG1

GENERAL INFORMATION

Gene namei

 ABCG1

Gene descriptioni

 ATP-binding cassette, sub-family G (WHITE), member 1

Protein classi

 Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localizationi

 Membrane,Secreted

Number of transcriptsi

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (MCF7, MOLT-4, SCLC-21H)
HPA (normal tissue):Expressed in all

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 General cytoplasmic expression, including macrophages.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Antibody staining mainly not consistent with RNA expression data.

Reliability scorei

 Approved based on 2 antibodies.
HPA031470 , HPA031471
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
HPA031470
HPA031471

GENE INFORMATIONi

Gene name

 ABCG1 (HGNC Symbol)

Synonyms

 ABC8

Description

 ATP-binding cassette, sub-family G (WHITE), member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 42199689 - 42297244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000160179 (version 83.38)

Entrez gene

 9619

UniProt

 P45844 (UniProt - Evidence at protein level)

neXtProt

 NX_P45844

Antibodypedia

 ABCG1 antibodies

PROTEIN BROWSERi
ABCG1-001
ABCG1-002
ABCG1-004
ABCG1-005
ABCG1-006
ABCG1-008
ABCG1-010

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCG1-001
ENSP00000381467
ENST00000398449
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
 666 aa
74.2 kDa 		Yes 7
ABCG1-002
ENSP00000381475
ENST00000398457
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
 668 aa
74.6 kDa 		No 7
ABCG1-004
ENSP00000291524
ENST00000347800
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
 663 aa
74 kDa 		No 7
ABCG1-005
ENSP00000339744
ENST00000343687
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
 677 aa
75.4 kDa 		No 7
ABCG1-006
ENSP00000354995
ENST00000361802
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010888 [negative regulation of lipid storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0030301 [cholesterol transport]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055099 [response to high density lipoprotein particle]
GO:1901998 [toxin transport]
Show all
 678 aa
75.6 kDa 		Yes 7
ABCG1-008
ENSP00000381464
ENST00000398437
E9PGV9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
Show all
 824 aa
90.9 kDa 		No 7
ABCG1-010
ENSP00000414541
ENST00000450121
C9JKD9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 257 aa
27.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.