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ABCG1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABCG1

Gene description

ATP-binding cassette, sub-family G (WHITE), member 1

Protein class

Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

Membrane,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression, including macrophages.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA031470 , HPA031471
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ABCG1 (HGNC Symbol)

Synonyms

ABC8

Description

ATP-binding cassette, sub-family G (WHITE), member 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

42199689 - 42297244

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160179 (version 83.38)

Entrez gene

9619

UniProt

P45844 (UniProt - Evidence at protein level)

neXtProt

NX_P45844

Antibodypedia

ABCG1 antibodies

PROTEIN BROWSER

ABCG1-001
ABCG1-002
ABCG1-004
ABCG1-005
ABCG1-006
ABCG1-008
ABCG1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG1-001
ENSP00000381467
ENST00000398449
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
666 aa
74.2 kDa
Yes 7
ABCG1-002
ENSP00000381475
ENST00000398457
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
668 aa
74.6 kDa
No 7
ABCG1-004
ENSP00000291524
ENST00000347800
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
663 aa
74 kDa
No 7
ABCG1-005
ENSP00000339744
ENST00000343687
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010887 [negative regulation of cholesterol storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:1901998 [toxin transport]
Show all
677 aa
75.4 kDa
No 7
ABCG1-006
ENSP00000354995
ENST00000361802
P45844 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005543 [phospholipid binding]
GO:0005548 [phospholipid transporter activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006810 [transport]
GO:0008203 [cholesterol metabolic process]
GO:0009720 [detection of hormone stimulus]
GO:0009897 [external side of plasma membrane]
GO:0010033 [response to organic substance]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010872 [regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0010888 [negative regulation of lipid storage]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019534 [toxin transporter activity]
GO:0030301 [cholesterol transport]
GO:0032367 [intracellular cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0033993 [response to lipid]
GO:0034041 [sterol-transporting ATPase activity]
GO:0034374 [low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034436 [glycoprotein transport]
GO:0034437 [glycoprotein transporter activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043531 [ADP binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055099 [response to high density lipoprotein particle]
GO:1901998 [toxin transport]
Show all
678 aa
75.6 kDa
Yes 7
ABCG1-008
ENSP00000381464
ENST00000398437
E9PGV9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0006810 [transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
Show all
824 aa
90.9 kDa
No 7
ABCG1-010
ENSP00000414541
ENST00000450121
C9JKD9 [Direct mapping]
ATP-binding cassette sub-family G member 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
257 aa
27.8 kDa
Yes 0

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